{"id":"98bc93d7-9c4a-56d6-801e-928047df43bc","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-nampt-sasp","predicate":"supports","statement":"NAMPT-supported NAD metabolism sustained glycolysis and respiration and promoted a proinflammatory SASP through the AMPK–p53–p38/NF-kappaB regulatory network in the tested senescent cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"67b07739-d37e-5447-bf35-3b9d8f71a28d","mechanism_event_label":"Supporting cellular metabolism can also support inflammatory secretion.","subject":{"id":"8272125c-0d87-5920-9dae-7409b797bbfa","slug":"nampt","display_name":"Human nicotinamide phosphoribosyltransferase / NAMPT","entity_type_key":"protein"},"object":{"id":"c46cbbd3-c7f6-5b16-8259-1da4b7db0f63","slug":"human-imr90-proinflammatory-sasp","display_name":"Proinflammatory SASP in human IMR90 fibroblasts","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"67b07739-d37e-5447-bf35-3b9d8f71a28d","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-nampt-sasp-event","event_type":"observed_relationship","label":"Supporting cellular metabolism can also support inflammatory secretion.","description":"NAMPT-supported NAD metabolism sustained glycolysis and respiration and promoted a proinflammatory SASP through the AMPK–p53–p38/NF-kappaB regulatory network in the tested senescent cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8272125c-0d87-5920-9dae-7409b797bbfa","slug":"nampt","display_name":"Human nicotinamide phosphoribosyltransferase / NAMPT","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c46cbbd3-c7f6-5b16-8259-1da4b7db0f63","slug":"human-imr90-proinflammatory-sasp","display_name":"Proinflammatory SASP in human IMR90 fibroblasts","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"283ed24b-06a1-50aa-9281-df3bac6ce37e","slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human IMR90 fibroblast senescence; NAMPT inhibition and knockdown.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not proof that NAD supplementation causes cancer in humans or that all senescent cells respond alike.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"NAD+ collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Supporting cellular metabolism can also support inflammatory secretion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"NAD+ metabolism governs the proinflammatory senescence-associated secretome. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30778219/ · DOI 10.1038/s41556-019-0287-4","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"019be766-c2bf-5dc6-b52c-b14d15876e8b","evidence_kind":"source_excerpt","locator":"Lines 156-162","start_line":156,"end_line":162,"excerpt":"## nad-plus-nampt-sasp\nSupporting cellular metabolism can also support inflammatory secretion.\nNAMPT-supported NAD metabolism sustained glycolysis and respiration and promoted a proinflammatory SASP through the AMPK–p53–p38/NF-kappaB regulatory network in the tested senescent cells.\nModel: Human IMR90 fibroblast senescence; NAMPT inhibition and knockdown.\nLimitations: Not proof that NAD supplementation causes cancer in humans or that all senescent cells respond alike.\nEvidence access: Primary full text\nNAD+ metabolism governs the proinflammatory senescence-associated secretome. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30778219/ · DOI 10.1038/s41556-019-0287-4","model_system":"Human IMR90 fibroblast senescence; NAMPT inhibition and knockdown.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f59aa302-d463-5462-876f-e21e64861eac","stable_key":"import-8c946991-97f0-55ee-8df0-00e67621962f","title":"NAD+: compartmental supply, consumption and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"9f5324d0d652c80ad630b3100e28ce34cd2ce260ea2e1324332a4262ce72ae09","revision_id":"0e07909c-e8bc-5950-bafc-61371d9d6412","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}