{"id":"9853f26c-e181-51eb-8489-b5633a758848","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-phgdh-treatment","predicate":"is_associated_with_improved","statement":"Amino-acid therapy over 3–7.5 years reduced seizure frequency in all five reported patients, with two becoming seizure-free; developmental progress was reported in only one early-treated patient.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"48441db0-f77d-5432-9791-cc99679dc47b","mechanism_event_label":"Restoring supply can help some outcomes without reversing every consequence.","subject":{"id":"c882cd0b-9d83-5b07-bd1c-fe4d45657dcb","slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"},"object":{"id":"14a63d94-e79d-53b5-bcca-7da28fd33631","slug":"human-phgdh-deficiency-seizures","display_name":"Seizure outcomes during amino-acid treatment of PHGDH deficiency","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"48441db0-f77d-5432-9791-cc99679dc47b","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-phgdh-treatment-event","event_type":"observed_relationship","label":"Restoring supply can help some outcomes without reversing every consequence.","description":"Amino-acid therapy over 3–7.5 years reduced seizure frequency in all five reported patients, with two becoming seizure-free; 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