{"id":"98364f80-ad50-5589-bd8c-6e640546d4b3","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-bhb-cytokines","predicate":"reduces","statement":"BHB reduced NLRP3-mediated IL-1beta and IL-18 production in human monocytes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"2c952a16-1c0b-59e4-a9f3-3dea61c8c620","mechanism_event_label":"The cellular signal changed selected cytokine outputs.","subject":{"id":"59496369-eea6-5302-a0a3-2dcfa8f2b71a","slug":"d-beta-hydroxybutyrate","display_name":"D-(R)-beta-hydroxybutyrate","entity_type_key":"small_molecule"},"object":{"id":"1f5fbd40-7c32-5e05-aaca-086f72ff1e1b","slug":"monocyte-il1b-il18-output","display_name":"Human monocyte IL-1beta and IL-18 production","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2c952a16-1c0b-59e4-a9f3-3dea61c8c620","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-bhb-cytokines-event","event_type":"observed_relationship","label":"The cellular signal changed selected cytokine outputs.","description":"BHB reduced NLRP3-mediated IL-1beta and IL-18 production in human monocytes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"59496369-eea6-5302-a0a3-2dcfa8f2b71a","slug":"d-beta-hydroxybutyrate","display_name":"D-(R)-beta-hydroxybutyrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1f5fbd40-7c32-5e05-aaca-086f72ff1e1b","slug":"monocyte-il1b-il18-output","display_name":"Human monocyte IL-1beta and IL-18 production","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a732d76c-af99-5440-b172-400274462345","slug":"nlrp3-inflammasome","display_name":"NLRP3 inflammasome","entity_type_key":"protein_complex"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human monocyte experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not universal anti-inflammatory activity or a clinical fasting outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"The cellular signal changed selected cytokine outputs.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25686106/ · DOI 10.1038/nm.3804","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"aa3bc9d4-febc-5336-a683-4127365dde19","evidence_kind":"source_excerpt","locator":"Lines 384-390","start_line":384,"end_line":390,"excerpt":"## fast-bhb-cytokines\nThe cellular signal changed selected cytokine outputs.\nBHB reduced NLRP3-mediated IL-1beta and IL-18 production in human monocytes.\nModel: Human monocyte experiments.\nLimitations: Not universal anti-inflammatory activity or a clinical fasting outcome.\nEvidence access: Primary abstract\nThe ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25686106/ · DOI 10.1038/nm.3804","model_system":"Human monocyte experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}