{"id":"9820c571-b2a5-5f9c-b3f0-ee7fc50b2990","stable_key":"e69ef6a0-0e23-5eac-aca1-cf333781b962:ino-phytate-iron","predicate":"inhibits","statement":"Adding sodium phytate to otherwise phytate-free wheat rolls inhibited iron absorption in a dose-dependent manner.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"98014100-fb08-57e4-9fc2-9b85fc124837","mechanism_event_label":"The six-phosphate form in food can reduce absorption of iron from that meal.","subject":{"id":"f64ba327-66e7-52b6-9424-7d7ec11acca4","slug":"phytic-acid","display_name":"Phytic acid / phytate","entity_type_key":"small_molecule"},"object":{"id":"4429d8ae-d732-5f5e-acc1-2c872e23da62","slug":"nonheme-iron-absorption","display_name":"Nonheme iron absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"98014100-fb08-57e4-9fc2-9b85fc124837","stable_key":"e69ef6a0-0e23-5eac-aca1-cf333781b962:ino-phytate-iron-event","event_type":"biochemical_relationship","label":"The six-phosphate form in food can reduce absorption of iron from that meal.","description":"Adding sodium phytate to otherwise phytate-free wheat rolls inhibited iron absorption in a dose-dependent manner.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f64ba327-66e7-52b6-9424-7d7ec11acca4","slug":"phytic-acid","display_name":"Phytic acid / phytate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4429d8ae-d732-5f5e-acc1-2c872e23da62","slug":"nonheme-iron-absorption","display_name":"Nonheme iron absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/inositol-research/2911999.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a5b0473a7a412eec5479259c7214b462fa6cfcc5948a6dae68db636de4e76f24\", \"start_char\": 0, \"end_char\": 943, \"text_sha256\": \"a5b0473a7a412eec5479259c7214b462fa6cfcc5948a6dae68db636de4e76f24\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Paired radioisotope meal-absorption study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Wheat rolls with increasing sodium phytate","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Luminal phytate/InsP6 exposure is distinct from free myo-inositol and intracellular InsP6 signaling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Inositol research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"inositol","display_name":"Inositol (stereoisomer family)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The six-phosphate form in food can reduce absorption of iron from that meal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ino-p2911999] Iron absorption in man: ascorbic acid and dose-dependent inhibition by phytate. 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