{"id":"97e380c3-e9bc-5272-920d-eba400688ff8","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-endothelial-sod","predicate":"increases_expression","statement":"Ergothioneine increased superoxide dismutase expression in the human endothelial-cell experiment.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"a8612017-f789-57c1-8db0-be73fae4604a","mechanism_event_label":"Another oxidant-handling enzyme accompanied the response.","subject":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"object":{"id":"320f21cc-534a-5670-8e4f-77b438131951","slug":"human-endothelial-sod-unresolved","display_name":"Human endothelial superoxide dismutase, isoform unresolved","entity_type_key":"protein_family"},"evidence_count":1,"mechanism_event":{"id":"a8612017-f789-57c1-8db0-be73fae4604a","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-endothelial-sod-event","event_type":"observed_relationship","label":"Another oxidant-handling enzyme accompanied the response.","description":"Ergothioneine increased superoxide dismutase expression in the human endothelial-cell experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"320f21cc-534a-5670-8e4f-77b438131951","slug":"human-endothelial-sod-unresolved","display_name":"Human endothelial superoxide dismutase, isoform unresolved","entity_type_key":"protein_family"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human brain microvascular endothelial cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Abstract does not resolve SOD1 versus SOD2; do not infer a specific copper, zinc or manganese requirement from this result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Another oxidant-handling enzyme accompanied the response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Uptake and protective effects of ergothioneine in human endothelial cells. · 2014 · https://pubmed.ncbi.nlm.nih.gov/25022513/ · DOI 10.1124/jpet.114.214049","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b6326638-8445-50bb-b6b1-fac10d883158","evidence_kind":"source_excerpt","locator":"Lines 568-574","start_line":568,"end_line":574,"excerpt":"## ergothioneine-endothelial-sod\nAnother oxidant-handling enzyme accompanied the response.\nErgothioneine increased superoxide dismutase expression in the human endothelial-cell experiment.\nModel: Human brain microvascular endothelial cells.\nLimitations: Abstract does not resolve SOD1 versus SOD2; do not infer a specific copper, zinc or manganese requirement from this result.\nEvidence access: Primary abstract\nUptake and protective effects of ergothioneine in human endothelial cells. · 2014 · https://pubmed.ncbi.nlm.nih.gov/25022513/ · DOI 10.1124/jpet.114.214049","model_system":"Human brain microvascular endothelial cells.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2f037d98-f3d0-5dbe-80d8-90b738f130d6","stable_key":"import-59b18080-c560-563d-abc5-bac4ee82a27c","title":"Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b6def8119f03cfabeec2fb55ba924340dc612e1dd42f05404201fa2b7ced5259","revision_id":"f88c38e6-ffb5-5a68-83ca-4610ca2c2df4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}