{"id":"97b3a4f4-df47-58c9-b1dd-e6ed7798abc8","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:cyclosporine-barely-inhibits-cerivastatin-metabolism","predicate":"does_not_significantly_inhibit_metabolism_of","statement":"Cyclosporin A inhibited the in vitro metabolism of labelled cerivastatin only at concentrations above 30 micromolar, two orders of magnitude above the concentrations that inhibited its transport.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"c7a4f980-9dce-5250-87b7-00383833a73d","mechanism_event_label":"Cyclosporin A inhibited the in vitro metabolism of labelled cerivastatin only at concentrations above 30 micromolar, two orders of magnitude above the concentrations that inhibited its transport.","subject":{"id":"b199063a-fae6-5c5c-9cb4-22c10453bbac","slug":"cyclosporine","display_name":"Cyclosporine","entity_type_key":"drug"},"object":{"id":"ade21be6-666e-59a9-8b89-06996f86551f","slug":"cerivastatin","display_name":"Cerivastatin","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"c7a4f980-9dce-5250-87b7-00383833a73d","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:cyclosporine-barely-inhibits-cerivastatin-metabolism-event","event_type":"biochemical_relationship","label":"Cyclosporin A inhibited the in vitro metabolism of labelled cerivastatin only at concentrations above 30 micromolar, two orders of magnitude above the concentrations that inhibited its transport.","description":"Drug metabolism","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b199063a-fae6-5c5c-9cb4-22c10453bbac","slug":"cyclosporine","display_name":"Cyclosporine","entity_type_key":"drug"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ade21be6-666e-59a9-8b89-06996f86551f","slug":"cerivastatin","display_name":"Cerivastatin","entity_type_key":"small_molecule"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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No reference carries a recorded retraction, erratum or expression of concern. Each of the seven is a separate laboratory and each carries its own lineage key, so none of them can be counted twice as independent support. Study-specific concentrations, kinetic constants and limitations retained. Not publisher full text.","file_path":"","sha256":"499d00555a629cba2271c3888d7e93627949891d565c4c78c843610de2913080","revision_id":"263ee68a-4184-51d0-a977-197d7ddb7a4d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}