{"id":"979d6b6e-b278-533c-9b6f-e39827ca1f26","stable_key":"e13b03e1-a614-543a-ac1b-97df18cfe30d:iron-alternate-absorption","predicate":"alternate_schedule_increased","statement":"Fractional iron absorption on the initial and alternate-day doses was 40–50% higher than on the consecutive-day dose.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6c2ddf92-db37-5f3f-b866-b2474b4e595c","mechanism_event_label":"Spacing changed absorption in this trial, but the study alone does not decide every patient’s regimen.","subject":{"id":"f20cb550-cb6b-5eab-a4d7-27537a5eb14b","slug":"ferrous-sulfate","display_name":"Ferrous sulfate","entity_type_key":"chemical_species"},"object":{"id":"4429d8ae-d732-5f5e-acc1-2c872e23da62","slug":"nonheme-iron-absorption","display_name":"Nonheme iron absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6c2ddf92-db37-5f3f-b866-b2474b4e595c","stable_key":"e13b03e1-a614-543a-ac1b-97df18cfe30d:iron-alternate-absorption-event","event_type":"biochemical_relationship","label":"Spacing changed absorption in this trial, but the study alone does not decide every patient’s regimen.","description":"Fractional iron absorption on the initial and alternate-day doses was 40–50% higher than on the consecutive-day dose.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f20cb550-cb6b-5eab-a4d7-27537a5eb14b","slug":"ferrous-sulfate","display_name":"Ferrous sulfate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4429d8ae-d732-5f5e-acc1-2c872e23da62","slug":"nonheme-iron-absorption","display_name":"Nonheme iron absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/iron-research/31413088.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8b12cbd03fa44886ae6bf6bd4d58db7bbbf21dad0461eef9b63d3c7da25c542c\", \"start_char\": 0, \"end_char\": 2483, \"text_sha256\": \"8b12cbd03fa44886ae6bf6bd4d58db7bbbf21dad0461eef9b63d3c7da25c542c\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Stable-isotope crossover absorption study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"100 or 200 mg ferrous sulfate on consecutive and alternate days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Absorption trial, not a universal dosing directive; the indexed abstract contains implausible units for baseline hemoglobin/ferritin, which are not reproduced as clinical thresholds.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"19 women with iron-deficiency anemia","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Spacing changed absorption in this trial, but the study alone does not decide every patient’s regimen.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iron-p31413088] Iron absorption from supplements is greater with alternate day than with consecutive day dosing in iron-deficient anemic women. 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