{"id":"97907c81-5d7a-5864-afda-ea4811e187a5","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-ears2-disease-metabolism","predicate":"alter_tested","statement":"Patient fibroblasts with EARS2 p.G317C had broad metabolic abnormalities; reconstitution with wild-type versus disease variants distinguished severity-related TCA and amino-acid signatures.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f0f8fcf1-5445-5fee-a2d6-716b2261aee4","mechanism_event_label":"A glutamate-handling translation enzyme can affect many downstream metabolic pools.","subject":{"id":"fcde64f8-8b88-5104-b58e-7d14080d5945","slug":"human-ears2-pathogenic-variants","display_name":"Human pathogenic EARS2 variants","entity_type_key":"cellular_process"},"object":{"id":"b6095e65-3335-5f7c-bb4a-cbc9b14d3005","slug":"human-ears2-fibroblast-metabolism","display_name":"Metabolism in human EARS2-deficient fibroblasts","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f0f8fcf1-5445-5fee-a2d6-716b2261aee4","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-ears2-disease-metabolism-event","event_type":"observed_relationship","label":"A glutamate-handling translation enzyme can affect many downstream metabolic pools.","description":"Patient fibroblasts with EARS2 p.G317C had broad metabolic abnormalities; 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