{"id":"970e02de-40a7-58aa-a9bc-8cc91f6c5254","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-bhb-potassium","predicate":"prevents","statement":"BHB prevented potassium efflux in the tested NLRP3 activation experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0926a572-e521-5294-b8ce-4cf6d52040c8","mechanism_event_label":"A ketone altered an ion movement involved in inflammatory signaling.","subject":{"id":"59496369-eea6-5302-a0a3-2dcfa8f2b71a","slug":"d-beta-hydroxybutyrate","display_name":"D-(R)-beta-hydroxybutyrate","entity_type_key":"small_molecule"},"object":{"id":"f80916f5-f209-5aca-b003-5abda80e6df4","slug":"macrophage-potassium-efflux","display_name":"Macrophage potassium efflux","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0926a572-e521-5294-b8ce-4cf6d52040c8","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-bhb-potassium-event","event_type":"observed_relationship","label":"A ketone altered an ion movement involved in inflammatory signaling.","description":"BHB prevented potassium efflux in the tested NLRP3 activation experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"59496369-eea6-5302-a0a3-2dcfa8f2b71a","slug":"d-beta-hydroxybutyrate","display_name":"D-(R)-beta-hydroxybutyrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f80916f5-f209-5aca-b003-5abda80e6df4","slug":"macrophage-potassium-efflux","display_name":"Macrophage potassium efflux","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b53e832d-0776-5495-b5cd-cb6a8e8c538b","slug":"nlrp3","display_name":"NLRP3","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Stimulated innate immune cells; both BHB enantiomers were active.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not evidence that BHB corrects systemic potassium deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"A ketone altered an ion movement involved in inflammatory signaling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25686106/ · DOI 10.1038/nm.3804","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"84fd6e9e-fb5d-59b1-a3bd-9ae3565d3bc9","evidence_kind":"source_excerpt","locator":"Lines 368-374","start_line":368,"end_line":374,"excerpt":"## fast-bhb-potassium\nA ketone altered an ion movement involved in inflammatory signaling.\nBHB prevented potassium efflux in the tested NLRP3 activation experiments.\nModel: Stimulated innate immune cells; both BHB enantiomers were active.\nLimitations: Not evidence that BHB corrects systemic potassium deficiency.\nEvidence access: Primary abstract\nThe ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25686106/ · DOI 10.1038/nm.3804","model_system":"Stimulated innate immune cells; both BHB enantiomers were active.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}