{"id":"96e4392b-f2c9-5499-ad4c-2c407e6070a6","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:ca-stim1-store-sensing","predicate":"senses","statement":"ER-store depletion causes STIM1 to redistribute into peripheral puncta through a mechanism requiring its luminal calcium-sensing region.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1071fa78-918a-5b0e-ac47-5d56c071c9a3","mechanism_event_label":"STIM1 detects falling calcium inside the ER.","subject":{"id":"f143762c-e7f0-54de-8ae3-cb2dcda9040e","slug":"stim1","display_name":"STIM1","entity_type_key":"protein"},"object":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"evidence_count":1,"mechanism_event":{"id":"1071fa78-918a-5b0e-ac47-5d56c071c9a3","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:ca-stim1-store-sensing-event","event_type":"regulation","label":"STIM1 detects falling calcium inside the ER.","description":"ER-store depletion causes STIM1 to redistribute into peripheral puncta through a mechanism requiring its luminal calcium-sensing region.","status":"provisional","compartment":{"slug":"endoplasmic-reticulum","display_name":"Endoplasmic reticulum"},"participants":[{"entity":{"id":"f143762c-e7f0-54de-8ae3-cb2dcda9040e","slug":"stim1","display_name":"STIM1","entity_type_key":"protein"},"role":"calcium_sensor","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"sensed_ligand","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ea69f7d2-43d8-5b62-8ed6-60d6ad580813","slug":"endoplasmic-reticulum","display_name":"Endoplasmic reticulum","entity_type_key":"organelle"},"role":"experimental_location","stoichiometry":null,"state_label":"","sequence_order":2,"notes":"Study location; presence here is not a separate transport or causal claim."},{"entity":{"id":"7df03d06-a2b7-524a-aa99-c9cf6a3bf4c2","slug":"er-membrane","display_name":"ER membrane","entity_type_key":"organelle"},"role":"experimental_location","stoichiometry":null,"state_label":"","sequence_order":3,"notes":"Study location; presence here is not a separate transport or causal claim."},{"entity":{"id":"f0b6bcb6-5d41-5d9d-af9f-6af1a94d5c5a","slug":"plasma-membrane","display_name":"Plasma membrane","entity_type_key":"organelle"},"role":"experimental_location","stoichiometry":null,"state_label":"","sequence_order":4,"notes":"Study location; presence here is not a separate transport or causal claim."}]},"contexts":[{"dimension":"compartment_description","value_text":"ER lumen and ER-plasma-membrane junctions","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human HeLa cells; RNA interference screen, calcium imaging and STIM1 EF-hand mutagenesis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Local store depletion is a cellular signal, not evidence of dietary calcium deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"STIM1 detects falling calcium inside the ER.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ca-liou2005] STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx (2005). https://pubmed.ncbi.nlm.nih.gov/16005298/ DOI: 10.1016/j.cub.2005.05.055","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"research_relationship_category","value_text":"regulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"HeLa cells","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1f3a878f-e6dc-5b94-bf95-480f0be6d5d9","evidence_kind":"source_excerpt","locator":"Lines 505-516","start_line":505,"end_line":516,"excerpt":"### ca-stim1-store-sensing\nER-store depletion causes STIM1 to redistribute into peripheral puncta through a mechanism requiring its luminal calcium-sensing region.\nCondition category: normal\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: STIM1 detects falling calcium inside the ER.\norganism: Homo sapiens\ntissue_or_cell_type: HeLa cells\nexperimental_model: Human HeLa cells; RNA interference screen, calcium imaging and STIM1 EF-hand mutagenesis\nlimitations: Local store depletion is a cellular signal, not evidence of dietary calcium deficiency.\nresearch_relationship_category: regulation\ncompartment_description: ER lumen and ER-plasma-membrane junctions\n[ca-liou2005] STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx (2005). https://pubmed.ncbi.nlm.nih.gov/16005298/ DOI: 10.1016/j.cub.2005.05.055","model_system":"Human HeLa cells; RNA interference screen, calcium imaging and STIM1 EF-hand mutagenesis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ca-liou2005] STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx (2005). https://pubmed.ncbi.nlm.nih.gov/16005298/ DOI: 10.1016/j.cub.2005.05.055","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3c083fa0-59c6-50e9-af42-678d0e3c1006","stable_key":"import-434e1e27-eb90-583a-956b-62472726ffba","title":"Calcium: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"965c934d6b147f2b62f8d45ce6d7a87681a600bfe5c46a585b4704889afd3fc1","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}