{"id":"96b3411e-7828-53d2-a4b5-29833fced33b","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-mitochondrial-sam-loss","predicate":"supports","statement":"Recessive SLC25A26 variants impaired mitochondrial methylation with defects in RNA stability, protein modification and translation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2133b466-e2fb-507b-abc0-4d6140817ce9","mechanism_event_label":"A compartment-specific shortage can occur without proving a dietary shortage.","subject":{"id":"4f2c512b-583e-5a31-9c5f-bc699742f86e","slug":"slc25a26","display_name":"Human mitochondrial SAM transporter / SLC25A26","entity_type_key":"protein"},"object":{"id":"7538bd91-d67c-546c-8a7f-b6dee5537266","slug":"human-slc25a26-mitochondrial-methylation","display_name":"Mitochondrial methylation and translation in SLC25A26 disease","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2133b466-e2fb-507b-abc0-4d6140817ce9","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-mitochondrial-sam-loss-event","event_type":"observed_relationship","label":"A compartment-specific shortage can occur without proving a dietary shortage.","description":"Recessive SLC25A26 variants impaired mitochondrial methylation with defects in RNA stability, protein modification and translation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4f2c512b-583e-5a31-9c5f-bc699742f86e","slug":"slc25a26","display_name":"Human mitochondrial SAM transporter / SLC25A26","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7538bd91-d67c-546c-8a7f-b6dee5537266","slug":"human-slc25a26-mitochondrial-methylation","display_name":"Mitochondrial methylation and translation in SLC25A26 disease","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"825f2da2-01bc-5874-a3c6-64f5ac867db5","slug":"s-adenosylmethionine","display_name":"S-Adenosyl-L-methionine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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