{"id":"96a526c9-0b94-5abc-a6bd-3b9211f5927c","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-late-challenge-insulin","predicate":"reduces","statement":"Insulin AUC was about 6.7% lower in the late condition.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d72cfe25-6ef7-53d3-8ea2-5821b43cec04","mechanism_event_label":"The glucose rise accompanied a weaker insulin response.","subject":{"id":"684791f6-7936-5cd4-aac1-8d8a07dae6a7","slug":"late-evening-glucose-challenge","display_name":"Late-evening glucose challenge relative to habitual bedtime","entity_type_key":"cellular_process"},"object":{"id":"4369a743-883d-5bb6-a0b0-edd41b31f7f3","slug":"glucose-challenge-insulin-auc","display_name":"Plasma insulin response to glucose challenge","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d72cfe25-6ef7-53d3-8ea2-5821b43cec04","stable_key":"3279ff78-2460-5064-bfc0-3f2987af85a0:melatonin-late-challenge-insulin-event","event_type":"observed_intervention","label":"The glucose rise accompanied a weaker insulin response.","description":"Insulin AUC was about 6.7% lower in the late condition.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"684791f6-7936-5cd4-aac1-8d8a07dae6a7","slug":"late-evening-glucose-challenge","display_name":"Late-evening glucose challenge relative to habitual bedtime","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4369a743-883d-5bb6-a0b0-edd41b31f7f3","slug":"glucose-challenge-insulin-auc","display_name":"Plasma insulin response to glucose challenge","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/melatonin-research/35015083.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"14878cd566ac009dde6fd0a6cc78adf1a4b48cfb2bc09e262568c909f84f236e\", \"start_char\": 0, \"end_char\": 1688, \"text_sha256\": \"14878cd566ac009dde6fd0a6cc78adf1a4b48cfb2bc09e262568c909f84f236e\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized crossover early versus late glucose-challenge study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"75 g OGTT four versus one hour before habitual bedtime after eight-hour fast","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Glucose drinks simulated meal timing. Timing, endogenous melatonin and other circadian factors co-varied; the intervention did not selectively manipulate melatonin alone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Melatonin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"melatonin","display_name":"Melatonin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"845 Spanish adults","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The glucose rise accompanied a weaker insulin response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[melatonin-p35015083] Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial. (2022). https://pubmed.ncbi.nlm.nih.gov/35015083/ DOI: 10.2337/dc21-1314","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Endogenous melatonin and evening glucose handling","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"05adf1bb-6670-5081-9cb9-6004882022d1","evidence_kind":"source_excerpt","locator":"Lines 1176-1187","start_line":1176,"end_line":1187,"excerpt":"### melatonin-late-challenge-insulin\nInsulin AUC was about 6.7% lower in the late condition.\nCondition category: normal\nnutrient_topic: Melatonin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The glucose rise accompanied a weaker insulin response.\norganism: 845 Spanish adults\ntissue_or_cell_type: Endogenous melatonin and evening glucose handling\nexperimental_model: Randomized crossover early versus late glucose-challenge study\nlimitations: Glucose drinks simulated meal timing. Timing, endogenous melatonin and other circadian factors co-varied; the intervention did not selectively manipulate melatonin alone.\nexposure: 75 g OGTT four versus one hour before habitual bedtime after eight-hour fast\nevidence_span: {\"source_cache\": \"artifacts/melatonin-research/35015083.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"14878cd566ac009dde6fd0a6cc78adf1a4b48cfb2bc09e262568c909f84f236e\", \"start_char\": 0, \"end_char\": 1688, \"text_sha256\": \"14878cd566ac009dde6fd0a6cc78adf1a4b48cfb2bc09e262568c909f84f236e\"}\n[melatonin-p35015083] Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial. (2022). https://pubmed.ncbi.nlm.nih.gov/35015083/ DOI: 10.2337/dc21-1314","model_system":"Randomized crossover early versus late glucose-challenge study","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [melatonin-p35015083] Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial. (2022). https://pubmed.ncbi.nlm.nih.gov/35015083/ DOI: 10.2337/dc21-1314","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bab588de-d217-5038-9c8b-b41222eba08b","stable_key":"import-3279ff78-2460-5064-bfc0-3f2987af85a0","title":"Melatonin: synthesis, receptors, circadian timing and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ff4f279d263f95a69da8e7e8a6c6318ab6ba1b55254dbbda1bfa9ce437e1db80","revision_id":"0318eef8-ff38-513e-8ffa-458146ca5e77","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}