{"id":"967686cc-f077-5c6f-a50a-abbe031f6c9a","stable_key":"16c35a72-8162-5bb1-ae01-45331b8b42d0:moringa-human-acute-glucose-null","predicate":"does_not_change","statement":"The same escalating-dose study found no difference in six-hour plasma glucose exposure after 0, 1, 2 or 4 g Moringa leaf powder.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"18d4e9f3-6a1a-5586-b60e-bc4563043917","mechanism_event_label":"The same escalating-dose study found no difference in six-hour plasma glucose exposure after 0, 1, 2 or 4 g Moringa leaf powder.","subject":{"id":"994f4608-74f6-55d1-b36b-f9284fce9960","slug":"moringa-leaf-powder","display_name":"Moringa dry leaf powder","entity_type_key":"botanical"},"object":{"id":"81404a14-36d7-533d-bb4e-848c4e3f4988","slug":"human-six-hour-plasma-glucose-auc","display_name":"Six-hour plasma glucose exposure after Moringa leaf powder","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"18d4e9f3-6a1a-5586-b60e-bc4563043917","stable_key":"16c35a72-8162-5bb1-ae01-45331b8b42d0:moringa-human-acute-glucose-null-event","event_type":"observed_relationship","label":"The same escalating-dose study found no difference in six-hour plasma glucose exposure after 0, 1, 2 or 4 g Moringa leaf powder.","description":"The same escalating-dose study found no difference in six-hour plasma glucose exposure after 0, 1, 2 or 4 g Moringa leaf powder.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"994f4608-74f6-55d1-b36b-f9284fce9960","slug":"moringa-leaf-powder","display_name":"Moringa dry leaf powder","entity_type_key":"botanical"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"81404a14-36d7-533d-bb4e-848c4e3f4988","slug":"human-six-hour-plasma-glucose-auc","display_name":"Six-hour plasma glucose exposure after Moringa leaf powder","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8ae7848b-f172-5e09-8acf-5ca914907b0b","slug":"glucose","display_name":"D-glucose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Single 0, 1, 2 and 4 g leaf-powder doses","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Six hours","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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(2016). https://pubmed.ncbi.nlm.nih.gov/27276742/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Plasma glucose concentration and AUC","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ddf4a463-dfa8-57cb-89e3-0c5a4bf80119","evidence_kind":"source_excerpt","locator":"Lines 123-132","start_line":123,"end_line":132,"excerpt":"## moringa-human-acute-glucose-null\nThe same escalating-dose study found no difference in six-hour plasma glucose exposure after 0, 1, 2 or 4 g Moringa leaf powder.\nModel/species: Ten healthy adults\nTissue/system: Plasma glucose concentration and AUC\nExposure: Single 0, 1, 2 and 4 g leaf-powder doses\nRoute: Oral\nDuration: Six hours\nLimits: A null acute glucose response in healthy adults does not exclude effects during chronic use or in dysglycemia.\nPrimary reference: Moringa Oleifera Leaf Increases Insulin Secretion after Single Dose Administration: A Preliminary Study in Healthy Subjects. (2016). https://pubmed.ncbi.nlm.nih.gov/27276742/\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Ten healthy adults","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2752e9b3-e4b9-55fe-be07-944204cca4b8","stable_key":"import-16c35a72-8162-5bb1-ae01-45331b8b42d0","title":"Moringa oleifera: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. 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