{"id":"96729332-70f8-5692-8962-8cd378cc6694","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-methanol-formate-tracer","predicate":"supplies_labeled_carbon_to","statement":"Labeled methanol inhalation produced labeled blood formate in cynomolgus monkeys.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0d1c625e-18fc-5a4c-a2c0-28117f3c9a34","mechanism_event_label":"A traced precursor-product link connects two separate metabolite nodes.","subject":{"id":"96bbf620-a0f1-506b-9f01-a4f1ea1224a9","slug":"methanol","display_name":"Methanol","entity_type_key":"small_molecule"},"object":{"id":"1fc1fa42-fcb5-5983-9a31-114703dc64c4","slug":"formate","display_name":"Formate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"0d1c625e-18fc-5a4c-a2c0-28117f3c9a34","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-methanol-formate-tracer-event","event_type":"observed_relationship","label":"A traced precursor-product link connects two separate metabolite nodes.","description":"Labeled methanol inhalation produced labeled blood formate in cynomolgus monkeys.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"96bbf620-a0f1-506b-9f01-a4f1ea1224a9","slug":"methanol","display_name":"Methanol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1fc1fa42-fcb5-5983-9a31-114703dc64c4","slug":"formate","display_name":"Formate","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Four female monkeys; lung-only exposure for two hours at 10–900 ppm.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not an aspartame feeding study; the route and systemic dose differ from digestion of a food sweetener.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Aspartame collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A traced precursor-product link connects two separate metabolite nodes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Pharmacokinetics of inhaled [14C]methanol and methanol-derived [14C]formate in normal and folate-deficient cynomolgus monkeys. · 1994 · https://pubmed.ncbi.nlm.nih.gov/7940538/ · DOI 10.1006/taap.1994.1202","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ba86d8b4-6264-5ee6-9dce-41a4629ceff1","evidence_kind":"source_excerpt","locator":"Lines 354-360","start_line":354,"end_line":360,"excerpt":"## aspartame-methanol-formate-tracer\nA traced precursor-product link connects two separate metabolite nodes.\nLabeled methanol inhalation produced labeled blood formate in cynomolgus monkeys.\nModel: Four female monkeys; lung-only exposure for two hours at 10–900 ppm.\nLimitations: Not an aspartame feeding study; the route and systemic dose differ from digestion of a food sweetener.\nEvidence access: Primary abstract\nPharmacokinetics of inhaled [14C]methanol and methanol-derived [14C]formate in normal and folate-deficient cynomolgus monkeys. · 1994 · https://pubmed.ncbi.nlm.nih.gov/7940538/ · DOI 10.1006/taap.1994.1202","model_system":"Four female monkeys; lung-only exposure for two hours at 10–900 ppm.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2bba7d36-993f-5ba7-acaf-2e4d573527ed","stable_key":"import-b428117d-3a8c-5e74-8711-168153e19545","title":"Aspartame: digestion, taste, metabolite dependencies and experimental signaling (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"21cfc6808062c6ea1fb5d34128bcd005d31f0f6c0d63484794238db77d32ae97","revision_id":"1255dda8-df99-5d4b-a65b-4144c47d7d9b","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}