{"id":"962f3a77-81e0-5993-9d22-4261a8dff796","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-coronavit-covid","predicate":"does-not-significantly-reduce","statement":"COVID-19 occurred in 2.6% of no-offer, 3.6% of lower-dose-offer and 3.0% of higher-dose-offer participants; ORs 1.39 (95% CI0.98–1.97) and 1.13 (0.78–1.63).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"6d862eb9-214e-5455-a7ce-ccf167da354e","mechanism_event_label":"The COVID-19 endpoint likewise showed no statistically clear protection.","subject":{"id":"43081f5e-3475-5969-b098-03e1b36126ac","slug":"vitamin-d-test-and-treat-offer","display_name":"Vitamin D testing and conditional supplementation offer","entity_type_key":"cellular_process"},"object":{"id":"1742814c-b793-5a79-8761-ec10d66a806e","slug":"covid-19-incidence","display_name":"Laboratory-confirmed COVID-19 incidence","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6d862eb9-214e-5455-a7ce-ccf167da354e","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-coronavit-covid-event","event_type":"observed_intervention","label":"The COVID-19 endpoint likewise showed no statistically clear protection.","description":"COVID-19 occurred in 2.6% of no-offer, 3.6% of lower-dose-offer and 3.0% of higher-dose-offer participants; ORs 1.39 (95% CI0.98–1.97) and 1.13 (0.78–1.63).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"43081f5e-3475-5969-b098-03e1b36126ac","slug":"vitamin-d-test-and-treat-offer","display_name":"Vitamin D testing and conditional supplementation offer","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1742814c-b793-5a79-8761-ec10d66a806e","slug":"covid-19-incidence","display_name":"Laboratory-confirmed COVID-19 incidence","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"CORONAVIT pragmatic randomized open-label offer-to-test-and-treat trial; 6200UKadults≥ 16","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Offer 800 or 3200 IU/day vitamin D for 6 months if 25(OH)D<75 nmol/L versus no offer; 2674 of 3100 offered received supplements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Open-label strategy trial; receipt, outside supplementation and pandemic context limit inference about specific cellular mechanisms or all dosing regimens.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The COVID-19 endpoint likewise showed no statistically clear protection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[jolliffe2022] Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT). (2022). https://pubmed.ncbi.nlm.nih.gov/36215226/ DOI: 10.1136/bmj-2022-071230","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Clinical respiratory outcomes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4f0b0c3c-cd17-5044-a12b-90cfc93c6253","evidence_kind":"source_excerpt","locator":"Lines 1665-1676","start_line":1665,"end_line":1676,"excerpt":"### vd-coronavit-covid\nCOVID-19 occurred in 2.6% of no-offer, 3.6% of lower-dose-offer and 3.0% of higher-dose-offer participants; ORs 1.39 (95% CI0.98–1.97) and 1.13 (0.78–1.63).\nCondition category: normal\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The COVID-19 endpoint likewise showed no statistically clear protection.\norganism: Homo sapiens\ntissue_or_cell_type: Clinical respiratory outcomes\nexperimental_model: CORONAVIT pragmatic randomized open-label offer-to-test-and-treat trial; 6200UKadults≥ 16\nlimitations: Open-label strategy trial; receipt, outside supplementation and pandemic context limit inference about specific cellular mechanisms or all dosing regimens.\nexposure: Offer 800 or 3200 IU/day vitamin D for 6 months if 25(OH)D<75 nmol/L versus no offer; 2674 of 3100 offered received supplements.\ncross_nutrient: false\n[jolliffe2022] Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT). 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(2022). https://pubmed.ncbi.nlm.nih.gov/36215226/ DOI: 10.1136/bmj-2022-071230","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c95c763c-5b31-5b3f-a2f8-2dfe5ef0d3ca","stable_key":"import-1deb434a-3547-51a0-a038-87b1ce79ec38","title":"Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"51004bf0d78db6146b8f198b0688a3cc7d4ea9822415a9c034f4c8790fb4e38b","revision_id":"d52ff207-a311-5f24-96f4-462838792db5","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}