{"id":"9622fbed-3052-5052-926a-c9a120f7fbdd","stable_key":"c8c7aa13-14c6-5f5c-9afc-9217d0f2f736:hfcs-dose-urate","predicate":"increases","statement":"Mean 24-hour urate increased with HFCS dose in the two-week study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"0c412aa7-01d0-5771-afc2-fee5063cd6e2","mechanism_event_label":"Mean 24-hour urate increased with HFCS dose in the two-week study.","subject":{"id":"9e77d6b7-d2b2-5fd5-a42a-6c4ff1885abf","slug":"hfcs-55","display_name":"HFCS-55","entity_type_key":"chemical_species"},"object":{"id":"9840d937-b945-5e6a-afc0-f6572e524080","slug":"human-plasma-urate","display_name":"Human plasma urate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0c412aa7-01d0-5771-afc2-fee5063cd6e2","stable_key":"c8c7aa13-14c6-5f5c-9afc-9217d0f2f736:hfcs-dose-urate-event","event_type":"observed_relationship","label":"Mean 24-hour urate increased with HFCS dose in the two-week study.","description":"Mean 24-hour urate increased with HFCS dose in the two-week study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9e77d6b7-d2b2-5fd5-a42a-6c4ff1885abf","slug":"hfcs-55","display_name":"HFCS-55","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9840d937-b945-5e6a-afc0-f6572e524080","slug":"human-plasma-urate","display_name":"Human plasma urate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"832b1926-18e7-5b76-8dc4-bad8ed234645","slug":"high-fructose-corn-syrup","display_name":"High-Fructose Corn Syrup / HFCS","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8b3659b4-1c0e-57f1-ae60-c9300b21359d","slug":"urate","display_name":"Urate / uric acid","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"HFCS-55 beverages at 0%, 10%, 17.5% or 25% energy requirement; 0% aspartame control","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Approximately 2 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract/metadata; unrecovered methods explicitly retained.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"85 adults aged 18-40; nonrandomized double-blinded matched groups","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_scope","value_text":"Direct HFCS-55 evidence","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Short biomarker study; outpatient calories were not fixed and clinical cardiovascular events were not measured. NCT01103921 overlaps HFCS/control participants with the 2021 report.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"HFCS chapter: actual formulation studies, component biochemistry and interventions are explicitly distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"high-fructose-corn-syrup","display_name":"High-Fructose Corn Syrup / HFCS","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"85 adults aged 18-40; nonrandomized double-blinded matched groups","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Mean 24-hour urate increased with HFCS dose in the two-week study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"A dose-response study of consuming high-fructose corn syrup-sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults. (2015). https://pubmed.ncbi.nlm.nih.gov/25904601/ DOI: 10.3945/ajcn.114.100461","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral beverages, with outpatient ad libitum diet and controlled inpatient meals","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Circulating lipids and urate","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c9c867c2-1a30-5dbf-9e41-82e5a13d6c3a","evidence_kind":"source_excerpt","locator":"Lines 305-315","start_line":305,"end_line":315,"excerpt":"## hfcs-dose-urate\nMean 24-hour urate increased with HFCS dose in the two-week study.\nModel/species: 85 adults aged 18-40; nonrandomized double-blinded matched groups\nTissue: Circulating lipids and urate\nExposure: HFCS-55 beverages at 0%, 10%, 17.5% or 25% energy requirement; 0% aspartame control\nRoute: Oral beverages, with outpatient ad libitum diet and controlled inpatient meals\nDuration: Approximately 2 weeks\nExposure scope: Direct HFCS-55 evidence\nLimits: Short biomarker study; outpatient calories were not fixed and clinical cardiovascular events were not measured. NCT01103921 overlaps HFCS/control participants with the 2021 report.\nReference: A dose-response study of consuming high-fructose corn syrup-sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults. (2015). https://pubmed.ncbi.nlm.nih.gov/25904601/ DOI: 10.3945/ajcn.114.100461\nAccess: Primary abstract/metadata; unrecovered methods explicitly retained.","model_system":"85 adults aged 18-40; nonrandomized double-blinded matched groups","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; provenance retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e863ddf6-7c1e-5a70-8335-7f3ac3eeee92","stable_key":"import-c8c7aa13-14c6-5f5c-9afc-9217d0f2f736","title":"High-Fructose Corn Syrup: mechanism of action and metabolic impact (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twenty primary studies and official FDA composition information, with one reused canonical glucose-transport claim. Study-specific citations, negative findings and limitations retained. Not publisher full text.","file_path":"","sha256":"f4721923a83b368d549ba110a4f8c8738026210b32f6d29f3bd3200aa420f3b3","revision_id":"45827d73-cb6d-5aff-969b-af364b74b168","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}