{"id":"95e23fa0-555d-548c-b1e0-62c798ce032b","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-cold-recovery-null","predicate":"did_not_significantly_accelerate","statement":"The tested commercial lozenge did not significantly improve ten-day recovery: zinc/placebo recovery-rate ratio .68 (95% CI .42–1.08; P=.10).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"99313bb6-6079-5e2e-bbf3-bb7ef80f6e39","mechanism_event_label":"A different acetate-lozenge regimen did not show faster recovery.","subject":{"id":"e3ffa4c2-7a90-54df-9c08-1a296e4f6c02","slug":"zinc-acetate","display_name":"Zinc acetate","entity_type_key":"chemical_species"},"object":{"id":"219e3709-7ce6-51f5-bf07-f81ba4d80b91","slug":"common-cold-recovery-rate","display_name":"Common cold recovery rate","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"99313bb6-6079-5e2e-bbf3-bb7ef80f6e39","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-cold-recovery-null-event","event_type":"observed_intervention","label":"A different acetate-lozenge regimen did not show faster recovery.","description":"The tested commercial lozenge did not significantly improve ten-day recovery: zinc/placebo recovery-rate ratio .68 (95% CI .42–1.08; P=.10).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e3ffa4c2-7a90-54df-9c08-1a296e4f6c02","slug":"zinc-acetate","display_name":"Zinc acetate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"219e3709-7ce6-51f5-bf07-f81ba4d80b91","slug":"common-cold-recovery-rate","display_name":"Common cold recovery rate","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Zinc exposure and the specifically measured response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Indexed primary abstract; accessible manuscript Methods and Results also inspected.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zinc-clinical-sources/hemila2020.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"581a713c4eeae243c2c96cb508cfe731318175d77c781476575775c09b6e9913\", \"utf8_bytes\": 2004}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind randomized placebo-controlled Finnish trial: 253 packages allocated; 87 colds analyzed","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Commercial acetate lozenges: 13 mg elemental zinc, six times daily, at most five days; nominal 78 mg/day.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This specific formulation dissolved in about eight minutes. Authors extended planned seven-day recovery analysis to ten days after finding no significant difference. Results do not identify why other formulations differ.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A different acetate-lozenge regimen did not show faster recovery.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zn-clin-hemila2020] Zinc acetate lozenges for the treatment of the common cold: a randomised controlled trial. (2020). https://pubmed.ncbi.nlm.nih.gov/31980506/ DOI: 10.1136/bmjopen-2019-031662","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Upper respiratory symptoms and tolerability","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5b0a1969-9add-55b8-9414-cc8c3c65e672","evidence_kind":"source_excerpt","locator":"Lines 1558-1571","start_line":1558,"end_line":1571,"excerpt":"### zn-clin-cold-recovery-null\nThe tested commercial lozenge did not significantly improve ten-day recovery: zinc/placebo recovery-rate ratio .68 (95% CI .42–1.08; P=.10).\nCondition category: normal\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A different acetate-lozenge regimen did not show faster recovery.\norganism: Homo sapiens\ntissue_or_cell_type: Upper respiratory symptoms and tolerability\nexperimental_model: Double-blind randomized placebo-controlled Finnish trial: 253 packages allocated; 87 colds analyzed\nlimitations: This specific formulation dissolved in about eight minutes. Authors extended planned seven-day recovery analysis to ten days after finding no significant difference. Results do not identify why other formulations differ.\nexposure: Commercial acetate lozenges: 13 mg elemental zinc, six times daily, at most five days; nominal 78 mg/day.\ncross_nutrient: Zinc exposure and the specifically measured response.\nevidence_location: Indexed primary abstract; accessible manuscript Methods and Results also inspected.\nevidence_span: {\"source_cache\": \"artifacts/zinc-clinical-sources/hemila2020.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"581a713c4eeae243c2c96cb508cfe731318175d77c781476575775c09b6e9913\", \"utf8_bytes\": 2004}\n[zn-clin-hemila2020] Zinc acetate lozenges for the treatment of the common cold: a randomised controlled trial. (2020). https://pubmed.ncbi.nlm.nih.gov/31980506/ DOI: 10.1136/bmjopen-2019-031662","model_system":"Double-blind randomized placebo-controlled Finnish trial: 253 packages allocated; 87 colds analyzed","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zn-clin-hemila2020] Zinc acetate lozenges for the treatment of the common cold: a randomised controlled trial. (2020). https://pubmed.ncbi.nlm.nih.gov/31980506/ DOI: 10.1136/bmjopen-2019-031662","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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