{"id":"95b0bc0c-35dc-5ad7-9a3d-6cd01672f096","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-stard7-mito","predicate":"mitochondrial_form_supports","statement":"Mitochondrial STARD7 preserved CoQ synthesis, oxidative phosphorylation and cristae organization.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cf154428-d2e6-58db-ba79-5186f5c8cd1d","mechanism_event_label":"The same protein has a different job when retained inside mitochondria.","subject":{"id":"afef27d7-c2cd-5d51-8f1f-330e16b21f48","slug":"stard7","display_name":"Human STARD7 lipid-transfer protein","entity_type_key":"protein"},"object":{"id":"06a23c22-a7a3-5fd8-af61-e67f96db8c51","slug":"coq-biosynthesis","display_name":"Coenzyme Q biosynthesis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cf154428-d2e6-58db-ba79-5186f5c8cd1d","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-stard7-mito-event","event_type":"biochemical_relationship","label":"The same protein has a different job when retained inside mitochondria.","description":"Mitochondrial STARD7 preserved CoQ synthesis, oxidative phosphorylation and cristae organization.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"afef27d7-c2cd-5d51-8f1f-330e16b21f48","slug":"stard7","display_name":"Human STARD7 lipid-transfer protein","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"06a23c22-a7a3-5fd8-af61-e67f96db8c51","slug":"coq-biosynthesis","display_name":"Coenzyme Q biosynthesis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/coq10-research/36658222.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8cd5c486ecb31ad03ea06a817eb5bc56e60abdfa8ae8d50a46502974be2898ce\", \"start_char\": 0, \"end_char\": 1410, \"text_sha256\": \"8cd5c486ecb31ad03ea06a817eb5bc56e60abdfa8ae8d50a46502974be2898ce\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Protein processing, localization, transport and cell-growth experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"PARL processing and compartment-specific STARD7 expression","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Intracellular distribution mechanism; increasing oral dose does not prove delivery to a particular organelle.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mammalian cell models","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The same protein has a different job when retained inside mitochondria.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[coq10-p36658222] Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7. (2023). https://pubmed.ncbi.nlm.nih.gov/36658222/ DOI: 10.1038/s41556-022-01071-y","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mitochondria and plasma membrane","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"308d1f85-2147-5855-989f-7d1398497b26","evidence_kind":"source_excerpt","locator":"Lines 489-500","start_line":489,"end_line":500,"excerpt":"### coq10-stard7-mito\nMitochondrial STARD7 preserved CoQ synthesis, oxidative phosphorylation and cristae organization.\nCondition category: normal\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The same protein has a different job when retained inside mitochondria.\norganism: Mammalian cell models\ntissue_or_cell_type: Mitochondria and plasma membrane\nexperimental_model: Protein processing, localization, transport and cell-growth experiments\nlimitations: Intracellular distribution mechanism; increasing oral dose does not prove delivery to a particular organelle.\nexposure: PARL processing and compartment-specific STARD7 expression\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/36658222.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8cd5c486ecb31ad03ea06a817eb5bc56e60abdfa8ae8d50a46502974be2898ce\", \"start_char\": 0, \"end_char\": 1410, \"text_sha256\": \"8cd5c486ecb31ad03ea06a817eb5bc56e60abdfa8ae8d50a46502974be2898ce\"}\n[coq10-p36658222] Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7. (2023). https://pubmed.ncbi.nlm.nih.gov/36658222/ DOI: 10.1038/s41556-022-01071-y","model_system":"Protein processing, localization, transport and cell-growth experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [coq10-p36658222] Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7. (2023). https://pubmed.ncbi.nlm.nih.gov/36658222/ DOI: 10.1038/s41556-022-01071-y","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fc6c2f3b-14a3-59de-848e-ca1c02fee1df","stable_key":"import-3b5aff9b-4086-5574-bfb4-3ea49ba520d7","title":"Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"053f9a6f6c17321fa9fd271486d7f20a86a49b237424108de7dc8663372e73bf","revision_id":"028900ce-8ca4-5d13-8c86-6e327c071e64","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}