{"id":"9591c1da-e91f-5cfd-afe6-4b18d6b82a52","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-suox-sqor","predicate":"loss_increases_abundance_of","statement":"The sulfite-accumulating cells had increased SQOR protein levels.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"37765fde-6ca6-5741-b2bb-6c246c97b55d","mechanism_event_label":"A separate sulfur-oxidation enzyme responded to the disturbance.","subject":{"id":"bf313203-7930-5d8b-9c8c-a10559dafcaf","slug":"suox","display_name":"Human sulfite oxidase / SUOX","entity_type_key":"protein"},"object":{"id":"6ddb0a1d-9690-5a4b-a837-052d69c7b88b","slug":"sqor","display_name":"Human sulfide:quinone oxidoreductase / SQOR","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"37765fde-6ca6-5741-b2bb-6c246c97b55d","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-suox-sqor-event","event_type":"biochemical_relationship","label":"A separate sulfur-oxidation enzyme responded to the disturbance.","description":"The sulfite-accumulating cells had increased SQOR protein levels.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bf313203-7930-5d8b-9c8c-a10559dafcaf","slug":"suox","display_name":"Human sulfite oxidase / SUOX","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6ddb0a1d-9690-5a4b-a837-052d69c7b88b","slug":"sqor","display_name":"Human sulfide:quinone oxidoreductase / SQOR","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/molybdenum-research/33271457.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"619710a31160db0927e01193e458277773ebe5e5423629e7dab58888ab6bc617\", \"start_char\": 0, \"end_char\": 1479, \"text_sha256\": \"619710a31160db0927e01193e458277773ebe5e5423629e7dab58888ab6bc617\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"CRISPR SUOX/GOT1/GOT2 perturbations and sulfur-metabolite assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Cysteine-sulfinate and H2S pathway experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cell-specific contributions; a higher concentration is not a direct measurement of pathway flux.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Molybdenum research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"molybdenum","display_name":"Molybdenum","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A separate sulfur-oxidation enzyme responded to the disturbance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mo-p33271457] The role of glutamate oxaloacetate transaminases in sulfite biosynthesis and H<sub>2</sub>S metabolism. (2021). https://pubmed.ncbi.nlm.nih.gov/33271457/ DOI: 10.1016/j.redox.2020.101800","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"HEK293T cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"5bba8751-2098-52f0-9c16-49f7f6b47a05","evidence_kind":"source_excerpt","locator":"Lines 729-740","start_line":729,"end_line":740,"excerpt":"### mo-suox-sqor\nThe sulfite-accumulating cells had increased SQOR protein levels.\nCondition category: machinery_impairment\nnutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A separate sulfur-oxidation enzyme responded to the disturbance.\norganism: Homo sapiens\ntissue_or_cell_type: HEK293T cells\nexperimental_model: CRISPR SUOX/GOT1/GOT2 perturbations and sulfur-metabolite assays\nlimitations: Cell-specific contributions; a higher concentration is not a direct measurement of pathway flux.\nexposure: Cysteine-sulfinate and H2S pathway experiments\nevidence_span: {\"source_cache\": \"artifacts/molybdenum-research/33271457.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"619710a31160db0927e01193e458277773ebe5e5423629e7dab58888ab6bc617\", \"start_char\": 0, \"end_char\": 1479, \"text_sha256\": \"619710a31160db0927e01193e458277773ebe5e5423629e7dab58888ab6bc617\"}\n[mo-p33271457] The role of glutamate oxaloacetate transaminases in sulfite biosynthesis and H<sub>2</sub>S metabolism. (2021). https://pubmed.ncbi.nlm.nih.gov/33271457/ DOI: 10.1016/j.redox.2020.101800","model_system":"CRISPR SUOX/GOT1/GOT2 perturbations and sulfur-metabolite assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mo-p33271457] The role of glutamate oxaloacetate transaminases in sulfite biosynthesis and H<sub>2</sub>S metabolism. (2021). https://pubmed.ncbi.nlm.nih.gov/33271457/ DOI: 10.1016/j.redox.2020.101800","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1aa6da60-8284-5252-8dd9-ac2250d5ced5","stable_key":"import-dc8975b1-95ff-5d9b-be17-a1c04610cca7","title":"Molybdenum: cofactor assembly, sulfur metabolism and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"143147eb9ac7fe750bdd33bb50d7773bc0cd49cc94faf219aebce3c3d760dd8f","revision_id":"90c2239d-290b-5e16-815a-f94d30569ebd","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}