{"id":"9558f9f0-69e4-5f52-9ecf-6f2274b36609","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-identity","predicate":"reported_relationship","statement":"Apigenin is 4′,5,7-trihydroxyflavone, C15H10O5, molecular mass about 270.24 g/mol; it lacks the adjacent B-ring hydroxyls present in luteolin.","claim_class":"identity","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"161f046b-7f97-5c5d-b9fb-2a8e0f2b89e4","mechanism_event_label":"Apigenin is 4′,5,7-trihydroxyflavone, C15H10O5, molecular mass about 270.24 g/mol; it lacks the adjacent B-ring hydroxyls present in luteolin.","subject":{"id":"4425961f-4764-56d3-9887-87e47749379b","slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"},"object":{"id":"4425961f-4764-56d3-9887-87e47749379b","slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"161f046b-7f97-5c5d-b9fb-2a8e0f2b89e4","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-identity-event","event_type":"experimental_observation","label":"Apigenin is 4′,5,7-trihydroxyflavone, C15H10O5, molecular mass about 270.24 g/mol; it lacks the adjacent B-ring hydroxyls present in luteolin.","description":"### api-identity\n\nApigenin is 4′,5,7-trihydroxyflavone, C15H10O5, molecular mass about 270.24 g/mol; it lacks the adjacent B-ring hydroxyls present in luteolin.\nAbsence of a catechol does not mean all metal binding or downstream methylation is impossible. Existing human CYP1A2 and CYP3A4 conversion-to-luteolin records are reused.\nModel and exposure: Chemical identity; not an intervention.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: PubChem CID 5280443: Apigenin | accessed 2026-10-10 | https://pubchem.ncbi.nlm.nih.gov/compound/5280443 | Access: Official chemical identity record; not a clinical experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4425961f-4764-56d3-9887-87e47749379b","slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"},"role":"recorded factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"4425961f-4764-56d3-9887-87e47749379b","slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Official chemical identity record; not a clinical experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Chemical identity; not an intervention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Apigenin collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Apigenin is 4′,5,7-trihydroxyflavone, C15H10O5, molecular mass about 270.24 g/mol; it lacks the adjacent B-ring hydroxyls present in luteolin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"PubChem CID 5280443: Apigenin | https://pubchem.ncbi.nlm.nih.gov/compound/5280443","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference api-identity; Absence of a catechol does not mean all metal binding or downstream methylation is impossible. Existing human CYP1A2 and CYP3A4 conversion-to-luteolin records are reused.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9279f897-bbde-5b7d-a5ad-a885f7bf6b4a","evidence_kind":"source_excerpt","locator":"Lines 21-27","start_line":21,"end_line":27,"excerpt":"### api-identity\n\nApigenin is 4′,5,7-trihydroxyflavone, C15H10O5, molecular mass about 270.24 g/mol; it lacks the adjacent B-ring hydroxyls present in luteolin.\nAbsence of a catechol does not mean all metal binding or downstream methylation is impossible. Existing human CYP1A2 and CYP3A4 conversion-to-luteolin records are reused.\nModel and exposure: Chemical identity; not an intervention.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: PubChem CID 5280443: Apigenin | accessed 2026-10-10 | https://pubchem.ncbi.nlm.nih.gov/compound/5280443 | Access: Official chemical identity record; not a clinical experiment.","model_system":"Chemical identity; not an intervention.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"54eac90b-add1-5f56-9036-d900307c5697","stable_key":"import-ff370329-68a3-573d-96ee-597de78a3967","title":"Apigenin: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"ede6e5c6b91d66b66844f2ff667a7f8303d9ac1281f15dc09db703f7de4da942","revision_id":"b41a39a2-0197-549c-97a5-1765e6696931","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}