{"id":"94eb19fc-2aae-50da-b538-634fc1334e6e","stable_key":"548ab9d6-3a9b-5bed-879c-17d03813b636:b2-critical-illness-pools","predicate":"diverged_from_redcell_fad_in_critical_illness","statement":"Critically ill patients had higher plasma riboflavin and FMN but lower plasma and red-cell FAD than healthy controls; plasma-vitamer relationships were disrupted.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"07ec1596-c167-5da9-a7cf-c94cb82b9eb0","mechanism_event_label":"A high circulating B2 concentration during critical illness can coexist with a lower measured cellular FAD pool.","subject":{"id":"e11125ef-6b45-542e-8517-1d8b299ad203","slug":"plasma-riboflavin-concentration","display_name":"Plasma riboflavin concentration","entity_type_key":"cellular_process"},"object":{"id":"dba23834-ae21-5eff-afc8-f504950bc8c6","slug":"erythrocyte-fad-concentration","display_name":"Erythrocyte FAD concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"07ec1596-c167-5da9-a7cf-c94cb82b9eb0","stable_key":"548ab9d6-3a9b-5bed-879c-17d03813b636:b2-critical-illness-pools-event","event_type":"observed_intervention","label":"A high circulating B2 concentration during critical illness can coexist with a lower measured cellular FAD pool.","description":"Critically ill patients had higher plasma riboflavin and FMN but lower plasma and red-cell FAD than healthy controls; plasma-vitamer relationships were disrupted.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8b1fa178-d59d-5a2d-a016-d97ac252c9db","slug":"plasma-fmn-concentration","display_name":"Plasma FMN concentration","entity_type_key":"cellular_process"},"role":"measured_marker","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"463817b6-5215-5439-8915-5f299d3a41da","slug":"plasma-fad-concentration","display_name":"Plasma FAD concentration","entity_type_key":"cellular_process"},"role":"measured_marker","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e2cd7179-f218-54e8-9ce9-7a836ae35fac","slug":"fad","display_name":"FAD","entity_type_key":"small_molecule"},"role":"cofactor","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"d3eacf85-1a35-546d-bd30-161474dd9691","slug":"fmn","display_name":"Flavin mononucleotide","entity_type_key":"small_molecule"},"role":"cofactor","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"e11125ef-6b45-542e-8517-1d8b299ad203","slug":"plasma-riboflavin-concentration","display_name":"Plasma riboflavin concentration","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"dba23834-ae21-5eff-afc8-f504950bc8c6","slug":"erythrocyte-fad-concentration","display_name":"Erythrocyte FAD concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"119 healthy controls and 125 critically ill patients at admission; repeat measurements in 60 patients.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Observational HPLC plasma and red-cell riboflavin, FMN andFAD; no isolated treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Observational illness comparison cannot diagnose tissue deficiency or establish that supplementation improves outcomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Riboflavin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A high circulating B2 concentration during critical illness can coexist with a lower measured cellular FAD pool.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b2-ventura2010] Relation between riboflavin, flavin mononucleotide and flavin adenine dinucleotide concentrations in plasma and red cells in patients with critical illness (2010). https://pubmed.ncbi.nlm.nih.gov/20667447/ DOI: 10.1016/j.cca.2010.07.024","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human clinical setting","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"e69f7782-3745-553f-93d9-44e826f24c5f","evidence_kind":"source_excerpt","locator":"Lines 1641-1651","start_line":1641,"end_line":1651,"excerpt":"### b2-critical-illness-pools\nCritically ill patients had higher plasma riboflavin and FMN but lower plasma and red-cell FAD than healthy controls; plasma-vitamer relationships were disrupted.\nCondition category: biomarker_context\nnutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A high circulating B2 concentration during critical illness can coexist with a lower measured cellular FAD pool.\norganism: Homo sapiens\ntissue_or_cell_type: Human clinical setting\nexperimental_model: 119 healthy controls and 125 critically ill patients at admission; repeat measurements in 60 patients.\nlimitations: Observational illness comparison cannot diagnose tissue deficiency or establish that supplementation improves outcomes.\nexposure: Observational HPLC plasma and red-cell riboflavin, FMN andFAD; no isolated treatment.\n[b2-ventura2010] Relation between riboflavin, flavin mononucleotide and flavin adenine dinucleotide concentrations in plasma and red cells in patients with critical illness (2010). https://pubmed.ncbi.nlm.nih.gov/20667447/ DOI: 10.1016/j.cca.2010.07.024","model_system":"119 healthy controls and 125 critically ill patients at admission; repeat measurements in 60 patients.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b2-ventura2010] Relation between riboflavin, flavin mononucleotide and flavin adenine dinucleotide concentrations in plasma and red cells in patients with critical illness (2010). https://pubmed.ncbi.nlm.nih.gov/20667447/ DOI: 10.1016/j.cca.2010.07.024","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4f7c9578-82bf-5e2d-b5c4-72a79fb4f6af","stable_key":"import-548ab9d6-3a9b-5bed-879c-17d03813b636","title":"Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"680cb6bc8249877f2410f551807f10d390fdd719014137d7414ba3420e29228d","revision_id":"7a61e299-908d-5372-860b-99ed190f9d7a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}