{"id":"944522d8-d977-5c55-8b13-3d0bb66288b1","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:macro-proportions-null","predicate":"no_detected_change_in_recorded_experiment","statement":"Modafinil did not selectively change the carbohydrate, fat and protein proportions of consumed calories in the short human food-intake study.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"6f860c62-9542-5b07-ac75-93517f70727d","mechanism_event_label":"Modafinil did not selectively change the carbohydrate, fat and protein proportions of consumed calories in the short human food-intake study.","subject":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"object":{"id":"3b0dcb42-4493-5866-a19c-ddf779e85cab","slug":"human-diet-macronutrient-proportions","display_name":"Human dietary macronutrient calorie proportions","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6f860c62-9542-5b07-ac75-93517f70727d","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:macro-proportions-null-event","event_type":"experimental_observation","label":"Modafinil did not selectively change the carbohydrate, fat and protein proportions of consumed calories in the short human food-intake study.","description":"In a double-blind simulated-shift-work study of **11 volunteers**, secondary analysis found approximately **18% and 38% lower caloric intake** with 200 and 400 mg modafinil, respectively. 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[Human food-intake study](https://pubmed.ncbi.nlm.nih.gov/18573275/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"role":"tested factor","stoichiometry":null,"state_label":"200 or 400 mg modafinil","sequence_order":0,"notes":""},{"entity":{"id":"3b0dcb42-4493-5866-a19c-ddf779e85cab","slug":"human-diet-macronutrient-proportions","display_name":"Human dietary macronutrient calorie proportions","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"no_detected_change","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary indexed abstract checked; full methods and figures not comprehensively reviewed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"200 or 400 mg modafinil\", \"comparator\": \"Placebo\", \"endpoint\": \"Modafinil did not selectively change the carbohydrate, fat and protein proportions of consumed calories in the short human food-intake study.\", \"effect_direction\": \"no_detected_change\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Eleven human volunteers; macronutrient proportions distinct from absolute energy intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. 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The proportions of calories from carbohydrate, fat and protein did not selectively change. Hunger ratings changed only at particular assessments; reduced intake remained across three exposure days. This supports an intake effect under those conditions, not demonstrated vitamin/mineral deficiency or a long-term weight-loss outcome. [Human food-intake study](https://pubmed.ncbi.nlm.nih.gov/18573275/)","model_system":"Eleven human volunteers; macronutrient proportions distinct from absolute energy intake.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. 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