{"id":"9400272e-0339-5365-8548-0486423e5306","stable_key":"d2e91bc7-8177-5ad3-ad9b-5d65813ce082:naringenin-naringin-conversion","predicate":"is_converted_by_human_fecal_microbes_to","statement":"Human fecal-water preparations converted naringin to naringenin in vitro.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"9c098325-9fda-5eee-a4fa-5daa099ec1d0","mechanism_event_label":"Human fecal-water preparations converted naringin to naringenin in vitro.","subject":{"id":"11a7a315-9779-5e16-8c18-307675a0c124","slug":"naringin","display_name":"Naringin","entity_type_key":"small_molecule"},"object":{"id":"2a9350f6-01cc-5bea-8213-cd3ebb1b05cf","slug":"naringenin","display_name":"Naringenin","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"9c098325-9fda-5eee-a4fa-5daa099ec1d0","stable_key":"d2e91bc7-8177-5ad3-ad9b-5d65813ce082:naringenin-naringin-conversion-event","event_type":"observed_relationship","label":"Human fecal-water preparations converted naringin to naringenin in vitro.","description":"Human fecal-water preparations converted naringin to naringenin in vitro.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"11a7a315-9779-5e16-8c18-307675a0c124","slug":"naringin","display_name":"Naringin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2a9350f6-01cc-5bea-8213-cd3ebb1b05cf","slug":"naringenin","display_name":"Naringenin","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Naringin incubation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Sampling through the incubation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Fecal water from six human donors","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Fecal-water conversion does not quantify in-vivo absorption or identify all organisms and enzymes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Naringenin chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"naringenin","display_name":"Naringenin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Fecal water from six human donors","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Human fecal-water preparations converted naringin to naringenin in vitro.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Human intestinal microbial metabolism of naringin. (2015). https://pubmed.ncbi.nlm.nih.gov/24935725/ DOI: 10.1007/s13318-014-0193-x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Ex vivo human microbial incubation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Anaerobic intestinal-microbial metabolism","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"007b7354-5d67-5c1c-9f1f-2221c1bb6c2e","evidence_kind":"source_excerpt","locator":"Lines 22-31","start_line":22,"end_line":31,"excerpt":"## naringenin-naringin-conversion\nHuman fecal-water preparations converted naringin to naringenin in vitro.\nModel/species: Fecal water from six human donors\nTissue/system: Anaerobic intestinal-microbial metabolism\nExposure: Naringin incubation\nRoute: Ex vivo human microbial incubation\nDuration: Sampling through the incubation\nLimits: Fecal-water conversion does not quantify in-vivo absorption or identify all organisms and enzymes.\nPrimary reference: Human intestinal microbial metabolism of naringin. (2015). https://pubmed.ncbi.nlm.nih.gov/24935725/ DOI: 10.1007/s13318-014-0193-x\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Fecal water from six human donors","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2804932d-46eb-5c43-8a45-0505e6b1ee05","stable_key":"import-d2e91bc7-8177-5ad3-ad9b-5d65813ce082","title":"Naringenin: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text.","file_path":"","sha256":"e74776bf312a9ab53a4510c483e36e3093829e8c38725b9ae061e59e86f1145a","revision_id":"b96b5487-2b33-56ff-8955-9e8c0833533b","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}