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Daily regimen differs from single-dose and food-fortification studies.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Both forms increased the blood marker in this daily-dose trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[holick2008] Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. (2008). https://pubmed.ncbi.nlm.nih.gov/18089691/ DOI: 10.1210/jc.2007-2308","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human circulating measurements","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d4ae3f49-7132-5e1a-a45c-a9470c6622b2","evidence_kind":"source_excerpt","locator":"Lines 1262-1273","start_line":1262,"end_line":1273,"excerpt":"### vd-holick-daily-d2\nMean serum total 25(OH)D rose from 16.9 to 26.8 ng/mL with daily D2; the study reported a comparable response to D3, which rose from 19.6 to 28.9 ng/mL.\nCondition category: normal\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Both forms increased the blood marker in this daily-dose trial.\norganism: Homo sapiens\ntissue_or_cell_type: Human circulating measurements\nexperimental_model: Double-blind placebo-controlled daily D2/D3/mixed trial; 68 adults represented in Fig.1; 11 weeks\nlimitations: Small groups and biochemical endpoints; authors reported comparable responses. Daily regimen differs from single-dose and food-fortification studies.\nexposure: Daily D2 1000 IU, D3 1000 IU, mixed 500+500 IU or placebo; 11 winter weeks.\ncross_nutrient: false\n[holick2008] Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. (2008). https://pubmed.ncbi.nlm.nih.gov/18089691/ DOI: 10.1210/jc.2007-2308","model_system":"Double-blind placebo-controlled daily D2/D3/mixed trial; 68 adults represented in Fig.1; 11 weeks","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [holick2008] Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. 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