{"id":"93be5ed1-fa8e-5f5e-a2dd-a879990fb7ed","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-sig-dendritic-chelation","predicate":"chelation_mimicked_stimulus_response","statement":"A zinc chelator mimicked the dendritic-cell effects of LPS in the primary study, which linked reduced intracellular free zinc to the maturation-marker response.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"ef990645-2a9b-5720-a287-12630885d3b0","mechanism_event_label":"Experimentally binding available zinc reproduced part of the dendritic-cell response.","subject":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"object":{"id":"d5eb167b-c8dc-5ace-a016-c1c02e0d889b","slug":"dendritic-cell-maturation-markers","display_name":"Dendritic-cell MHC-II and costimulatory markers","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ef990645-2a9b-5720-a287-12630885d3b0","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-sig-dendritic-chelation-event","event_type":"biochemical_relationship","label":"Experimentally binding available zinc reproduced part of the dendritic-cell response.","description":"A zinc chelator mimicked the dendritic-cell effects of LPS in the primary study, which linked reduced intracellular free zinc to the maturation-marker response.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d5eb167b-c8dc-5ace-a016-c1c02e0d889b","slug":"dendritic-cell-maturation-markers","display_name":"Dendritic-cell MHC-II and costimulatory markers","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Zinc(II) ion (availability_modifier)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zinc-signaling-sources/16892068-abstract.txt\", \"locator\": \"Primary indexed abstract\", \"file_sha256\": \"922aedddf1d5d49fc62e39285307917b93201e23b5b7ea57a60136edd6762a17\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Dendritic-cell signaling study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Experimental zinc chelation, not dietary zinc restriction. Chelator identity, concentration and exposure time are not verified in the indexed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Chelation is a manipulation of available cellular zinc. It is not evidence for a human intake threshold or a universal immune benefit of low zinc.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Experimentally binding available zinc reproduced part of the dendritic-cell response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zn-sig-16892068] Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. (2006). https://pubmed.ncbi.nlm.nih.gov/16892068/ DOI: 10.1038/ni1373","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Dendritic cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"d2e2ba4c-1f0d-546c-b3f5-d60aee8feda5","evidence_kind":"source_excerpt","locator":"Lines 1167-1179","start_line":1167,"end_line":1179,"excerpt":"### zn-sig-dendritic-chelation\nA zinc chelator mimicked the dendritic-cell effects of LPS in the primary study, which linked reduced intracellular free zinc to the maturation-marker response.\nCondition category: nutrient_deficiency\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Experimentally binding available zinc reproduced part of the dendritic-cell response.\norganism: Mus musculus\ntissue_or_cell_type: Dendritic cells\nexperimental_model: Dendritic-cell signaling study\nlimitations: Chelation is a manipulation of available cellular zinc. It is not evidence for a human intake threshold or a universal immune benefit of low zinc.\nexposure: Experimental zinc chelation, not dietary zinc restriction. Chelator identity, concentration and exposure time are not verified in the indexed abstract.\ncross_nutrient: Zinc(II) ion (availability_modifier)\nevidence_span: {\"source_cache\": \"artifacts/zinc-signaling-sources/16892068-abstract.txt\", \"locator\": \"Primary indexed abstract\", \"file_sha256\": \"922aedddf1d5d49fc62e39285307917b93201e23b5b7ea57a60136edd6762a17\"}\n[zn-sig-16892068] Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. (2006). https://pubmed.ncbi.nlm.nih.gov/16892068/ DOI: 10.1038/ni1373","model_system":"Dendritic-cell signaling study","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zn-sig-16892068] Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. (2006). https://pubmed.ncbi.nlm.nih.gov/16892068/ DOI: 10.1038/ni1373","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"2e731dd54477ec1254e97df3323e1208d38f1375effed19252e71ab4f600d13a","revision_id":"c72258b9-ac09-5408-9d44-a921ad1f96a3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}