{"id":"937e9c04-124b-5cd4-9408-576eabec2f15","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-sodium-renal-context","predicate":"increases","statement":"Indomethacin increased fractional lithium reabsorption on both high- and low-sodium diets in seven volunteers.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2f1e77c6-04d7-5eb6-8028-dda051ad5c3b","mechanism_event_label":"Sodium intake changes the setting for a drug interaction.","subject":{"id":"b4ad67ed-ff1f-5c41-a6a4-040205a3bdf3","slug":"indomethacin","display_name":"Indomethacin","entity_type_key":"small_molecule"},"object":{"id":"d5c45c9c-0abb-5bd0-94a7-7f0b4e670824","slug":"human-renal-lithium-reabsorption","display_name":"Human renal lithium reabsorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2f1e77c6-04d7-5eb6-8028-dda051ad5c3b","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-sodium-renal-context-event","event_type":"observed_relationship","label":"Sodium intake changes the setting for a drug interaction.","description":"Indomethacin increased fractional lithium reabsorption on both high- and low-sodium diets in seven volunteers.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b4ad67ed-ff1f-5c41-a6a4-040205a3bdf3","slug":"indomethacin","display_name":"Indomethacin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d5c45c9c-0abb-5bd0-94a7-7f0b4e670824","slug":"human-renal-lithium-reabsorption","display_name":"Human renal lithium reabsorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"200 versus 40 mmol/day sodium; reabsorption 71 to 75% and 75 to 81%, respectively.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a recommendation to change salt intake; lithium clearance was not a universally pure proximal-tubule marker.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Sodium intake changes the setting for a drug interaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Indomethacin increases renal lithium reabsorption in man. · 1989 · https://pubmed.ncbi.nlm.nih.gov/2494594/","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"73174b21-cf43-5f6b-b136-c108536b7e42","evidence_kind":"source_excerpt","locator":"Lines 368-374","start_line":368,"end_line":374,"excerpt":"## lithium-sodium-renal-context\nSodium intake changes the setting for a drug interaction.\nIndomethacin increased fractional lithium reabsorption on both high- and low-sodium diets in seven volunteers.\nModel: 200 versus 40 mmol/day sodium; reabsorption 71 to 75% and 75 to 81%, respectively.\nLimitations: Not a recommendation to change salt intake; lithium clearance was not a universally pure proximal-tubule marker.\nEvidence access: Primary abstract\nIndomethacin increases renal lithium reabsorption in man. · 1989 · https://pubmed.ncbi.nlm.nih.gov/2494594/","model_system":"200 versus 40 mmol/day sodium; reabsorption 71 to 75% and 75 to 81%, respectively.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b2dd2f3c-5c4c-5a12-9a0d-91b521ffcf98","stable_key":"import-b7798a90-72a3-5454-a321-c4be88bf0cc4","title":"Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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