{"id":"937300da-67ab-57f0-bc0a-4ab16c1a48e4","stable_key":"d96b230c-481b-535b-930c-04eb87ec7f02:s-allylcysteine-mouse-nrf2","predicate":"increases_tested_abundance_of","statement":"SAC administration increased Nrf2 protein and antioxidant-response signaling in the mouse ischemia study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"e9ec6560-76d6-55a7-812c-899f6d0433c9","mechanism_event_label":"A cellular defense response changed after treatment.","subject":{"id":"8c2c295d-68b3-5e62-b1a7-00fcf915e3cc","slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"},"object":{"id":"95319607-3946-51b3-8235-400ec3223692","slug":"mouse-nfe2l2","display_name":"Mouse Nrf2 / Nfe2l2","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"e9ec6560-76d6-55a7-812c-899f6d0433c9","stable_key":"d96b230c-481b-535b-930c-04eb87ec7f02:s-allylcysteine-mouse-nrf2-event","event_type":"observed_relationship","label":"A cellular defense response changed after treatment.","description":"SAC administration increased Nrf2 protein and antioxidant-response signaling in the mouse ischemia study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8c2c295d-68b3-5e62-b1a7-00fcf915e3cc","slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"95319607-3946-51b3-8235-400ec3223692","slug":"mouse-nfe2l2","display_name":"Mouse Nrf2 / Nfe2l2","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"acting_entity","value_text":"s-allylcysteine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"dose","value_text":"Not specified in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Not specified in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_comparison","value_text":"SAC versus ischemic control; 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