{"id":"92e9da75-22c5-540a-b238-d628a6562c3d","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:cyclosporine-does-not-change-claudin-19","predicate":"does_not_change_expression_of","statement":"Cyclosporine did not change renal expression of claudin-19 in the same rat model, reported alongside the unchanged claudin-16.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"d7e8e653-e4f5-5e49-b96c-1813b2ddaf8e","mechanism_event_label":"Cyclosporine did not change renal expression of claudin-19 in the same rat model, reported alongside the unchanged claudin-16.","subject":{"id":"b199063a-fae6-5c5c-9cb4-22c10453bbac","slug":"cyclosporine","display_name":"Cyclosporine","entity_type_key":"drug"},"object":{"id":"e3555ad8-2e1f-5526-a2fd-48bcff6c4590","slug":"rat-claudin-19","display_name":"Rat claudin-19","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"d7e8e653-e4f5-5e49-b96c-1813b2ddaf8e","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:cyclosporine-does-not-change-claudin-19-event","event_type":"observed_intervention","label":"Cyclosporine did not change renal expression of claudin-19 in the same rat model, reported alongside the unchanged claudin-16.","description":"Kidney","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b199063a-fae6-5c5c-9cb4-22c10453bbac","slug":"cyclosporine","display_name":"Cyclosporine","entity_type_key":"drug"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e3555ad8-2e1f-5526-a2fd-48bcff6c4590","slug":"rat-claudin-19","display_name":"Rat claudin-19","entity_type_key":"protein"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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