{"id":"92db5494-b94c-5332-865c-b2e5b03c0663","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-intestinal-allocation","predicate":"is_incorporated_into","statement":"Piglet portal-drained viscera used a large fraction of dietary threonine, mainly through incorporation into mucosal proteins; dietary supply was preferentially used over systemic supply under normal-protein feeding.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"997c16d1-fb11-5355-9605-84598512c967","mechanism_event_label":"The gut uses much of the incoming amino acid before it reaches other tissues.","subject":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"object":{"id":"1f84d5cd-6415-5f6b-8136-a4219ee456ec","slug":"pig-intestinal-mucosal-protein","display_name":"Pig intestinal mucosal protein","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"997c16d1-fb11-5355-9605-84598512c967","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-intestinal-allocation-event","event_type":"observed_relationship","label":"The gut uses much of the incoming amino acid before it reaches other tissues.","description":"Piglet portal-drained viscera used a large fraction of dietary threonine, mainly through incorporation into mucosal proteins; 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species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The gut uses much of the incoming amino acid before it reaches other tissues.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Threonine utilization is high in the intestine of piglets. · 2005 · https://pubmed.ncbi.nlm.nih.gov/15795432/ · DOI 10.1093/jn/135.4.765","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cd8a12e6-becf-51fb-bc08-67b39d688c25","evidence_kind":"source_excerpt","locator":"Lines 202-208","start_line":202,"end_line":208,"excerpt":"## l-threonine-intestinal-allocation\nThe gut uses much of the incoming amino acid before it reaches other tissues.\nPiglet portal-drained viscera used a large fraction of dietary threonine, mainly through incorporation into mucosal proteins; dietary supply was preferentially used over systemic supply under normal-protein feeding.\nModel: 18 piglets, normal or protein-restricted isocaloric feeding; stable-isotope tracing after seven hours of enteral feeding.\nLimitations: Reported 91% versus 85% dietary utilization is specific to this model and feeding interval, not a human universal fraction.\nEvidence access: Primary abstract\nThreonine utilization is high in the intestine of piglets. · 2005 · https://pubmed.ncbi.nlm.nih.gov/15795432/ · DOI 10.1093/jn/135.4.765","model_system":"18 piglets, normal or protein-restricted isocaloric feeding; stable-isotope tracing after seven hours of enteral feeding.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"35396730-235a-537e-8a05-c6ef2960c509","stable_key":"import-97957230-601f-5dec-8524-0812be8fadbf","title":"L-Threonine: translation, intestinal barrier, metabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"3365aed939d9f567bd098449c7d67c7c00fb6c9ba163dcf34dc7cf6081f324fb","revision_id":"10a7b648-8dd7-5d4e-b618-c560a6e2d3c7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}