{"id":"92990083-6be5-5926-9dad-d4ad8c07d2b1","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-human-women-null","predicate":"did_not_improve","statement":"In nonobese postmenopausal women with normal glucose tolerance, 75 mg/day resveratrol for 12 weeks did not improve liver, muscle or adipose insulin sensitivity or measured AMPK/SIRT1/NAMPT/PPARGC1A targets.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"a590d822-2713-525e-a935-29abdd8b88ad","mechanism_event_label":"Effects in metabolically abnormal models do not automatically transfer to healthy people.","subject":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"cefc5aa8-ad4e-5060-b6f3-d4f64da6c361","slug":"human-nonobese-women-resveratrol-metabolism","display_name":"Metabolic outcomes in nonobese postmenopausal women","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a590d822-2713-525e-a935-29abdd8b88ad","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-human-women-null-event","event_type":"observed_relationship","label":"Effects in metabolically abnormal models do not automatically transfer to healthy people.","description":"In nonobese postmenopausal women with normal glucose tolerance, 75 mg/day resveratrol for 12 weeks did not improve liver, muscle or adipose insulin sensitivity or measured AMPK/SIRT1/NAMPT/PPARGC1A targets.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cefc5aa8-ad4e-5060-b6f3-d4f64da6c361","slug":"human-nonobese-women-resveratrol-metabolism","display_name":"Metabolic outcomes in nonobese postmenopausal women","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b8e1bfa9-c412-5f35-97af-cfc722123d27","slug":"sirt1","display_name":"SIRT1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8272125c-0d87-5920-9dae-7409b797bbfa","slug":"nampt","display_name":"Human nicotinamide phosphoribosyltransferase / NAMPT","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Null result is population- and regimen-specific.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; 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