{"id":"9286fa2b-c4e3-526f-9106-a2d9d66689e8","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iodine-trans-lactation-mrna","predicate":"increases_abundance","statement":"Mouse mammary Slc5a5 mRNA abundance increased during lactation.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"a714dd39-4f09-58b3-b60b-2671d9548c45","mechanism_event_label":"The lactating mouse mammary gland increases the transcript for the iodide transporter.","subject":{"id":"ca2083f7-7b4a-5343-9fb8-a60662e66225","slug":"mammary-lactation","display_name":"Mammary lactation","entity_type_key":"cellular_process"},"object":{"id":"36027a20-5d39-59d8-bc2e-74ae21c558eb","slug":"mouse-slc5a5-mrna","display_name":"Mouse Slc5a5 messenger RNA","entity_type_key":"rna"},"evidence_count":1,"mechanism_event":{"id":"a714dd39-4f09-58b3-b60b-2671d9548c45","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iodine-trans-lactation-mrna-event","event_type":"observed_intervention","label":"The lactating mouse mammary gland increases the transcript for the iodide transporter.","description":"Mouse mammary Slc5a5 mRNA abundance increased during lactation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c299de06-e4da-5991-9723-75c623c63a23","slug":"mouse-slc5a5","display_name":"Mouse sodium/iodide symporter / Slc5a5","entity_type_key":"protein"},"role":"encoded_protein","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"role":"transported_substrate","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ca2083f7-7b4a-5343-9fb8-a60662e66225","slug":"mammary-lactation","display_name":"Mammary lactation","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"36027a20-5d39-59d8-bc2e-74ae21c558eb","slug":"mouse-slc5a5-mrna","display_name":"Mouse Slc5a5 messenger RNA","entity_type_key":"rna"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Lactating and comparator mouse mammary tissues; mouse NIS cDNA cloning","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Lactating versus comparison mammary tissues; dietary doses not specified.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Transcript abundance is not a direct milk-transfer rate or evidence for a human supplement dose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The lactating mouse mammary gland increases the transcript for the iodide transporter.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iodine-trans-lactation2001] Cloning of the mouse sodium iodide symporter and its expression in the mammary gland and other tissues. (2001). https://pubmed.ncbi.nlm.nih.gov/11431151/ DOI: 10.1677/joe.0.1700185","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mammary gland","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8b4705ba-6836-5223-b3c4-2956ea0042f3","evidence_kind":"source_excerpt","locator":"Lines 271-282","start_line":271,"end_line":282,"excerpt":"### iodine-trans-lactation-mrna\nMouse mammary Slc5a5 mRNA abundance increased during lactation.\nCondition category: normal\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The lactating mouse mammary gland increases the transcript for the iodide transporter.\norganism: Mus musculus\ntissue_or_cell_type: Mammary gland\nexperimental_model: Lactating and comparator mouse mammary tissues; mouse NIS cDNA cloning\nlimitations: Transcript abundance is not a direct milk-transfer rate or evidence for a human supplement dose.\nexposure: Lactating versus comparison mammary tissues; dietary doses not specified.\ncross_nutrient: false\n[iodine-trans-lactation2001] Cloning of the mouse sodium iodide symporter and its expression in the mammary gland and other tissues. (2001). https://pubmed.ncbi.nlm.nih.gov/11431151/ DOI: 10.1677/joe.0.1700185","model_system":"Lactating and comparator mouse mammary tissues; mouse NIS cDNA cloning","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iodine-trans-lactation2001] Cloning of the mouse sodium iodide symporter and its expression in the mammary gland and other tissues. (2001). https://pubmed.ncbi.nlm.nih.gov/11431151/ DOI: 10.1677/joe.0.1700185","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"76da623d-a34a-5a5c-a942-d7571a85c486","stable_key":"import-aaa7baba-8689-56ab-ba1e-b71542bcb8e9","title":"Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a4885eb6f58bad4a4514c958b63834619e57b10aa7f694aa97d0f65c7d36548f","revision_id":"ea8001a1-b576-5eda-a193-883c7ad59b73","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}