{"id":"9268527a-1ef3-5929-a77d-17c1ee92e410","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-fgf21-restriction","predicate":"when_restricted_engages","statement":"Dietary threonine restriction produced systemic metabolic remodeling in mice that required liver-derived FGF21.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e2095cf2-987a-559d-a46d-e67f6c4673b9","mechanism_event_label":"A liver hormone mediates part of the organism-level response to restricted supply.","subject":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"object":{"id":"c2efb5e5-3604-5db1-ae26-381bbbbd372e","slug":"mouse-threonine-fgf21-remodeling","display_name":"Mouse threonine-restriction metabolic remodeling","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e2095cf2-987a-559d-a46d-e67f6c4673b9","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-fgf21-restriction-event","event_type":"observed_relationship","label":"A liver hormone mediates part of the organism-level response to restricted supply.","description":"Dietary threonine restriction produced systemic metabolic remodeling in mice that required liver-derived FGF21.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c2efb5e5-3604-5db1-ae26-381bbbbd372e","slug":"mouse-threonine-fgf21-remodeling","display_name":"Mouse threonine-restriction metabolic remodeling","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8b01fe3c-a32b-5076-9c61-34d4d35e8b89","slug":"mouse-fgf21","display_name":"Mouse fibroblast growth factor 21 / Fgf21","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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