{"id":"91d560ff-a9c7-5214-a118-413614f6a16e","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-human-glycine-tracer","predicate":"contributes_label_to","statement":"A study in six adult men detected limited threonine-derived glycine labeling, accounting for an estimated 7–11% of threonine catabolism under its model.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"db2a9e9b-a7c3-5626-9618-e1878eed07ef","mechanism_event_label":"Detecting carbon transfer does not identify the enzyme responsible.","subject":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"object":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"db2a9e9b-a7c3-5626-9618-e1878eed07ef","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-human-glycine-tracer-event","event_type":"observed_relationship","label":"Detecting carbon transfer does not identify the enzyme responsible.","description":"A study in six adult men detected limited threonine-derived glycine labeling, accounting for an estimated 7–11% of threonine catabolism under its model.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Four-hour labeled-threonine/glycine infusions under control and high-threonine diets.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The paper called this TDG flux before the human TDH pseudogene was characterized. Retain the tracer observation without asserting functional human TDH; alternative routes were not resolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Threonine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Detecting carbon transfer does not identify the enzyme responsible.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Threonine dehydrogenase is a minor degradative pathway of threonine catabolism in adult humans. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10780944/ · DOI 10.1152/ajpendo.2000.278.5.E877","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f6782c81-8364-5133-bbcf-a63770ad6952","evidence_kind":"source_excerpt","locator":"Lines 290-296","start_line":290,"end_line":296,"excerpt":"## l-threonine-human-glycine-tracer\nDetecting carbon transfer does not identify the enzyme responsible.\nA study in six adult men detected limited threonine-derived glycine labeling, accounting for an estimated 7–11% of threonine catabolism under its model.\nModel: Four-hour labeled-threonine/glycine infusions under control and high-threonine diets.\nLimitations: The paper called this TDG flux before the human TDH pseudogene was characterized. Retain the tracer observation without asserting functional human TDH; alternative routes were not resolved.\nEvidence access: Primary abstract\nThreonine dehydrogenase is a minor degradative pathway of threonine catabolism in adult humans. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10780944/ · DOI 10.1152/ajpendo.2000.278.5.E877","model_system":"Four-hour labeled-threonine/glycine infusions under control and high-threonine diets.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"35396730-235a-537e-8a05-c6ef2960c509","stable_key":"import-97957230-601f-5dec-8524-0812be8fadbf","title":"L-Threonine: translation, intestinal barrier, metabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"3365aed939d9f567bd098449c7d67c7c00fb6c9ba163dcf34dc7cf6081f324fb","revision_id":"10a7b648-8dd7-5d4e-b618-c560a6e2d3c7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}