{"id":"91cf38f1-4985-5d7e-b2b9-9bba3ecd072f","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-surgery-blood","predicate":"reduces","statement":"Preoperative SSKI reduced mean estimated blood loss from 162 to 62 mL; adjusted comparison P=0.036.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"2386d4b7-4e9f-5534-b6ca-4629e9603c57","mechanism_event_label":"One randomized surgical trial found less bleeding.","subject":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"object":{"id":"e9b2b4c0-9325-5b8b-8843-5f8f40a1182d","slug":"thyroidectomy-blood-loss","display_name":"Blood loss during thyroidectomy","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2386d4b7-4e9f-5534-b6ca-4629e9603c57","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-surgery-blood-event","event_type":"observed_relationship","label":"One randomized surgical trial found less bleeding.","description":"Preoperative SSKI reduced mean estimated blood loss from 162 to 62 mL; adjusted comparison P=0.036.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e9b2b4c0-9325-5b8b-8843-5f8f40a1182d","slug":"thyroidectomy-blood-loss","display_name":"Blood loss during thyroidectomy","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Randomized SSKI versus no-SSKI Graves thyroidectomy trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Study-specific effect; operative-time reduction was not significant.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"One randomized surgical trial found less bleeding.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Randomized trial of a short course of preoperative potassium iodide in patients undergoing thyroidectomy for Graves' disease. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27769543/ · DOI 10.1016/j.amjsurg.2016.07.015","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"15f073cd-a7d8-5b76-be66-49fd73d1f87f","evidence_kind":"source_excerpt","locator":"Lines 408-414","start_line":408,"end_line":414,"excerpt":"## ki-surgery-blood\nOne randomized surgical trial found less bleeding.\nPreoperative SSKI reduced mean estimated blood loss from 162 to 62 mL; adjusted comparison P=0.036.\nModel: Randomized SSKI versus no-SSKI Graves thyroidectomy trial.\nLimitations: Study-specific effect; operative-time reduction was not significant.\nEvidence location: Primary abstract\nRandomized trial of a short course of preoperative potassium iodide in patients undergoing thyroidectomy for Graves' disease. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27769543/ · DOI 10.1016/j.amjsurg.2016.07.015","model_system":"Randomized SSKI versus no-SSKI Graves thyroidectomy trial.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-study references, chemical references and label statements individually identified. Not publisher full text.","file_path":"","sha256":"3ff9da818dd7a763a59c6abcff2eaee136d7f887a777034feaa5ba304a8fa6ce","revision_id":"53f2ae88-8a91-5326-ac49-3bb510ca78c3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}