{"id":"91baa9bc-7710-53ab-9b12-3f02f6902c6e","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-mucosal-loss","predicate":"has_reduced_activity_in","statement":"Diseased intestinal mucosa showed reduced brush-border and cytosolic Asp-Phe hydrolase activity alongside reductions in other enzymes.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"12513d23-847b-5cf0-93ba-febebfdf7ce0","mechanism_event_label":"General mucosal disease can change digestive capacity.","subject":{"id":"213bda8b-72ce-552b-a22b-fd4b5420f9ed","slug":"human-diseased-mucosa-asp-phe-hydrolase","display_name":"Asp-Phe hydrolase activity in diseased human intestinal mucosa","entity_type_key":"cellular_process"},"object":{"id":"164d6ac3-0038-5071-b0dc-d6774ef52141","slug":"human-intestinal-aspartame-hydrolysis","display_name":"Human intestinal microvillar aspartame hydrolysis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"12513d23-847b-5cf0-93ba-febebfdf7ce0","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-mucosal-loss-event","event_type":"observed_relationship","label":"General mucosal disease can change digestive capacity.","description":"Diseased intestinal mucosa showed reduced brush-border and cytosolic Asp-Phe hydrolase activity alongside reductions in other enzymes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"213bda8b-72ce-552b-a22b-fd4b5420f9ed","slug":"human-diseased-mucosa-asp-phe-hydrolase","display_name":"Asp-Phe hydrolase activity in diseased human intestinal mucosa","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"164d6ac3-0038-5071-b0dc-d6774ef52141","slug":"human-intestinal-aspartame-hydrolysis","display_name":"Human intestinal microvillar aspartame hydrolysis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"4cf892ac-f3f0-5e54-994e-509758cb3ce3","slug":"alpha-l-aspartyl-l-phenylalanine","display_name":"Alpha-L-aspartyl-L-phenylalanine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human mucosal enzyme comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No demonstrated aspartame-sensitivity syndrome or successful enzyme repletion was established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Aspartame collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"General mucosal disease can change digestive capacity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Intestinal hydrolysis of aspartylphenylalanine--the metabolic product of aspartame. · 1986 · https://pubmed.ncbi.nlm.nih.gov/3743970/ · DOI 10.1016/0016-5085(86)90697-9","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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