{"id":"91ba3b7c-d7e3-5f72-ace8-610f1274b0c8","stable_key":"cfa4bd86-d88d-555a-975c-68877bf00e0f:lutein-human-beta-absorption","predicate":"reduces_in_trial","statement":"Adding lutein reduced the postprandial beta-carotene response, more strongly when lutein predominated.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b5465827-42c4-5434-85a1-34f61b4a90f6","mechanism_event_label":"The ratio of carotenoids mattered in the test meal.","subject":{"id":"5dd84367-3f8e-5a3f-b952-a96174ea51fa","slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"},"object":{"id":"0c7abce1-a93a-53e7-b279-e09023beacf8","slug":"postmeal-beta-carotene-response","display_name":"Human post-meal plasma beta-carotene response","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b5465827-42c4-5434-85a1-34f61b4a90f6","stable_key":"cfa4bd86-d88d-555a-975c-68877bf00e0f:lutein-human-beta-absorption-event","event_type":"observed_intervention","label":"The ratio of carotenoids mattered in the test meal.","description":"Adding lutein reduced the postprandial beta-carotene response, more strongly when lutein predominated.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5dd84367-3f8e-5a3f-b952-a96174ea51fa","slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0c7abce1-a93a-53e7-b279-e09023beacf8","slug":"postmeal-beta-carotene-response","display_name":"Human post-meal plasma beta-carotene response","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lutein-research/9857262.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"22d6d633851b14b6c170fecfb2b3ef493c263f1640d690a2ee3a1d3bf9ccc77f\", \"start_char\": 0, \"end_char\": 892, \"text_sha256\": \"22d6d633851b14b6c170fecfb2b3ef493c263f1640d690a2ee3a1d3bf9ccc77f\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Original single-meal volunteer data reported alongside a literature discussion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Beta-carotene alone or combined with lutein; beta-carotene:lutein ratios 2:1 and 1:2","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Record uses the original experiment, not the review portion; reduced uptake did not imply impaired cleavage of absorbed beta-carotene.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lutein research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The ratio of carotenoids mattered in the test meal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lutein-p9857262] Effect of lutein on beta-carotene absorption and cleavage. 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