{"id":"91acf31f-15e5-56d0-a369-7a6ae7d8b807","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:cal-pregnancy-tanzania-preterm","predicate":"has_reported_effect_on","statement":"The lower regimen did not meet preterm-live-birth noninferiority in Tanzania.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7fa7458c-020b-519d-bc7a-d34d18dd9377","mechanism_event_label":"The Tanzania estimate was too uncertain to meet the same threshold.","subject":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"object":{"id":"77d9d9e5-22bf-5dac-a2a7-fc08eeb38ade","slug":"preterm-live-birth","display_name":"Preterm live birth","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7fa7458c-020b-519d-bc7a-d34d18dd9377","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:cal-pregnancy-tanzania-preterm-event","event_type":"observed_intervention","label":"The Tanzania estimate was too uncertain to meet the same threshold.","description":"The lower regimen did not meet preterm-live-birth noninferiority in Tanzania.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"role":"tested_input","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"77d9d9e5-22bf-5dac-a2a7-fc08eeb38ade","slug":"preterm-live-birth","display_name":"Preterm live birth","entity_type_key":"cellular_process"},"role":"measured_outcome","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Tanzania component of the two trials.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"RR 1.07, 95% CI 0.95-1.21; margin 1.16.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Failure to establish noninferiority does not prove inferiority or harm.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The Tanzania estimate was too uncertain to meet the same threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[cal-clin-dwarkanath2024] Two Randomized Trials of Low-Dose Calcium Supplementation in Pregnancy (2024). https://www.nejm.org/doi/full/10.1056/NEJMoa2307212 DOI: 10.1056/NEJMoa2307212","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human clinical or absorption endpoint","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6a20299a-aa60-5d38-ba3e-cca3a18a0d41","evidence_kind":"source_excerpt","locator":"Lines 1377-1387","start_line":1377,"end_line":1387,"excerpt":"### cal-pregnancy-tanzania-preterm\nThe lower regimen did not meet preterm-live-birth noninferiority in Tanzania.\nCondition category: normal\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The Tanzania estimate was too uncertain to meet the same threshold.\norganism: Homo sapiens\ntissue_or_cell_type: Human clinical or absorption endpoint\nexperimental_model: Tanzania component of the two trials.\nlimitations: Failure to establish noninferiority does not prove inferiority or harm.\nexposure: RR 1.07, 95% CI 0.95-1.21; margin 1.16.\n[cal-clin-dwarkanath2024] Two Randomized Trials of Low-Dose Calcium Supplementation in Pregnancy (2024). https://www.nejm.org/doi/full/10.1056/NEJMoa2307212 DOI: 10.1056/NEJMoa2307212","model_system":"Tanzania component of the two trials.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [cal-clin-dwarkanath2024] Two Randomized Trials of Low-Dose Calcium Supplementation in Pregnancy (2024). https://www.nejm.org/doi/full/10.1056/NEJMoa2307212 DOI: 10.1056/NEJMoa2307212","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3c083fa0-59c6-50e9-af42-678d0e3c1006","stable_key":"import-434e1e27-eb90-583a-956b-62472726ffba","title":"Calcium: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"965c934d6b147f2b62f8d45ce6d7a87681a600bfe5c46a585b4704889afd3fc1","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[{"id":"3056e1b2-fd31-5058-9516-a211f7b3dbcd","title":"Preterm-birth noninferiority differed between India and Tanzania","kind":"context_difference","status":"open","why":"The same noninferiority margin was met in India but not Tanzania. This is an uncertainty/design distinction, not proof of harm in Tanzania; population explanations remain hypotheses.","resolution":"Unresolved; needs review.","created_at":"2026-09-17 08:08:54","record_type":"conflict","display_label":"Recorded conflict","record_url":"/conflicts/3056e1b2-fd31-5058-9516-a211f7b3dbcd","sides":[{"conflict_id":"3056e1b2-fd31-5058-9516-a211f7b3dbcd","ordinal":0,"label":"The India result met the planned comparison threshold.","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","start_line":1365,"end_line":1375,"quote":"### cal-pregnancy-india-preterm\nThe lower calcium regimen met the preterm-live-birth noninferiority criterion in India.\nCondition category: normal\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The India result met the planned comparison threshold.\norganism: Homo sapiens\ntissue_or_cell_type: Human clinical or absorption endpoint\nexperimental_model: India component of the two trials.\nlimitations: No untreated control; noninferiority need not generalize to another setting.\nexposure: RR 0.89, 95% CI 0.80-0.98; margin 1.16.\n[cal-clin-dwarkanath2024] Two Randomized Trials of Low-Dose Calcium Supplementation in Pregnancy (2024). https://www.nejm.org/doi/full/10.1056/NEJMoa2307212 DOI: 10.1056/NEJMoa2307212","source_key":"import-434e1e27-eb90-583a-956b-62472726ffba","source_title":"Calcium: mechanism-first literature curation (2026-09-17)","claim_ids":["13eade16-a004-5a2c-99ce-ca9e21da239d"]},{"conflict_id":"3056e1b2-fd31-5058-9516-a211f7b3dbcd","ordinal":1,"label":"The Tanzania estimate was too uncertain to meet the same threshold.","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","start_line":1377,"end_line":1387,"quote":"### cal-pregnancy-tanzania-preterm\nThe lower regimen did not meet preterm-live-birth noninferiority in Tanzania.\nCondition category: normal\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The Tanzania estimate was too uncertain to meet the same threshold.\norganism: Homo sapiens\ntissue_or_cell_type: Human clinical or absorption endpoint\nexperimental_model: Tanzania component of the two trials.\nlimitations: Failure to establish noninferiority does not prove inferiority or harm.\nexposure: RR 1.07, 95% CI 0.95-1.21; margin 1.16.\n[cal-clin-dwarkanath2024] Two Randomized Trials of Low-Dose Calcium Supplementation in Pregnancy (2024). https://www.nejm.org/doi/full/10.1056/NEJMoa2307212 DOI: 10.1056/NEJMoa2307212","source_key":"import-434e1e27-eb90-583a-956b-62472726ffba","source_title":"Calcium: mechanism-first literature curation (2026-09-17)","claim_ids":["91acf31f-15e5-56d0-a369-7a6ae7d8b807"]}]}],"corrections":[],"research":null}