{"id":"915b2c70-b111-5c0b-85c9-8156ee48f74e","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-salt-bone-model","predicate":"higher_intake_changes","statement":"Higher salt shifted modeled bone calcium balance from positive to negative on the higher-calcium diet; balance was negative at both salt levels on the lower-calcium diet.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"fd409ef3-4187-5dcb-82b2-683445fb1dd5","mechanism_event_label":"Calcium intake changed the context of the modeled salt effect; this was not a fracture trial.","subject":{"id":"f3fe99b8-4e4a-57cd-9a86-3651092c9f6c","slug":"sodium-chloride","display_name":"Sodium chloride","entity_type_key":"chemical_species"},"object":{"id":"28327daf-b1bf-51d7-91ed-09e3e7bec11c","slug":"modeled-bone-calcium-balance","display_name":"Modeled bone calcium balance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fd409ef3-4187-5dcb-82b2-683445fb1dd5","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-salt-bone-model-event","event_type":"observed_intervention","label":"Calcium intake changed the context of the modeled salt effect; this was not a fracture trial.","description":"Higher salt shifted modeled bone calcium balance from positive to negative on the higher-calcium diet; balance was negative at both salt levels on the lower-calcium diet.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"balance_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f3fe99b8-4e4a-57cd-9a86-3651092c9f6c","slug":"sodium-chloride","display_name":"Sodium chloride","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"28327daf-b1bf-51d7-91ed-09e3e7bec11c","slug":"modeled-bone-calcium-balance","display_name":"Modeled bone calcium balance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/sodium-research/18410231.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f831f038a6c4249510bbeeae68778a216f1c36aa440e33816072959d1a07fefa\", \"start_char\": 0, \"end_char\": 1558, \"text_sha256\": \"f831f038a6c4249510bbeeae68778a216f1c36aa440e33816072959d1a07fefa\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized crossover with stable-isotope calcium measures and compartmental modeling in 11 completers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Four five-week calcium/salt diet combinations: 518 or 1284 mg calcium; 3.9 or 11.2 g salt daily","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small study; bone balance was modeled, fractures were not measured. Salt means sodium chloride, not elemental sodium.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sodium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sodium","display_name":"Sodium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human postmenopausal women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Calcium intake changed the context of the modeled salt effect; this was not a fracture trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sodium-p18410231] Sodium and bone health: impact of moderately high and low salt intakes on calcium metabolism in postmenopausal women. (2008). https://pubmed.ncbi.nlm.nih.gov/18410231/ DOI: 10.1359/jbmr.080408","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestinal, renal and modeled skeletal calcium balance","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0ecd588d-dde9-53e8-a975-06d020f3c33b","evidence_kind":"source_excerpt","locator":"Lines 1123-1134","start_line":1123,"end_line":1134,"excerpt":"### sodium-salt-bone-model\nHigher salt shifted modeled bone calcium balance from positive to negative on the higher-calcium diet; balance was negative at both salt levels on the lower-calcium diet.\nCondition category: normal\nnutrient_topic: Sodium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Calcium intake changed the context of the modeled salt effect; this was not a fracture trial.\norganism: Human postmenopausal women\ntissue_or_cell_type: Intestinal, renal and modeled skeletal calcium balance\nexperimental_model: Randomized crossover with stable-isotope calcium measures and compartmental modeling in 11 completers\nlimitations: Small study; bone balance was modeled, fractures were not measured. Salt means sodium chloride, not elemental sodium.\nexposure: Four five-week calcium/salt diet combinations: 518 or 1284 mg calcium; 3.9 or 11.2 g salt daily\nevidence_span: {\"source_cache\": \"artifacts/sodium-research/18410231.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f831f038a6c4249510bbeeae68778a216f1c36aa440e33816072959d1a07fefa\", \"start_char\": 0, \"end_char\": 1558, \"text_sha256\": \"f831f038a6c4249510bbeeae68778a216f1c36aa440e33816072959d1a07fefa\"}\n[sodium-p18410231] Sodium and bone health: impact of moderately high and low salt intakes on calcium metabolism in postmenopausal women. (2008). https://pubmed.ncbi.nlm.nih.gov/18410231/ DOI: 10.1359/jbmr.080408","model_system":"Randomized crossover with stable-isotope calcium measures and compartmental modeling in 11 completers","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [sodium-p18410231] Sodium and bone health: impact of moderately high and low salt intakes on calcium metabolism in postmenopausal women. (2008). https://pubmed.ncbi.nlm.nih.gov/18410231/ DOI: 10.1359/jbmr.080408","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c260cd7b-beb0-5113-a198-69ec8fd4492c","stable_key":"import-195e8b84-ca5a-591a-a045-c55c53c8a01c","title":"Sodium: gradients, nutrient transport, fluid regulation and loss states (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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