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topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Xenopus expression system","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Magnesium-bound ADP helps keep this potassium channel active.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[gribble-1997-sur1] The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide (1997). https://pmc.ncbi.nlm.nih.gov/articles/PMC1169713/ DOI: 10.1093/emboj/16.6.1145","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Oocyte membrane","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1ef03cdb-2a62-5b72-995c-42684d209210","evidence_kind":"source_excerpt","locator":"Lines 810-820","start_line":810,"end_line":820,"excerpt":"### k-mgadp-sur1-activation\nMgADP potentiated cloned Kir6.2/SUR1 current through intact SUR1 nucleotide-binding machinery.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Magnesium-bound ADP helps keep this potassium channel active.\norganism: Xenopus expression system\ntissue_or_cell_type: Oocyte membrane\nexperimental_model: Xenopus oocyte cloned-channel patches.\nlimitations: Heterologous channel biochemistry, not nutritional magnesium depletion.\ncross_nutrient: MgADP supplies a magnesium-dependent regulatory input to potassium conductance.\n[gribble-1997-sur1] The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide (1997). https://pmc.ncbi.nlm.nih.gov/articles/PMC1169713/ DOI: 10.1093/emboj/16.6.1145","model_system":"Xenopus oocyte cloned-channel patches.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [gribble-1997-sur1] The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide (1997). https://pmc.ncbi.nlm.nih.gov/articles/PMC1169713/ DOI: 10.1093/emboj/16.6.1145","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}