{"id":"91567457-12a0-54ad-9a21-c8a150b9da61","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-romk-enac-conditional-k-secretory-chain","predicate":"supports-driving-force-for","statement":"The mouse findings support a model in which sustained ENaC sodium entry and higher ROMK conductance jointly favor potassium secretion during combined Na/Mg restriction.","claim_class":"hypothesis_link","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"abaf0468-2e37-5117-a5fc-21668c617b0a","mechanism_event_label":"Sodium entry changes the electrical conditions for potassium exit; lifting the Mg brake on ROMK matters when that driving force is available.","subject":{"id":"b6e8049f-ad5c-5ca0-ba73-1d4392131397","slug":"enac","display_name":"Epithelial sodium channel","entity_type_key":"protein_complex"},"object":{"id":"00c10917-2733-5c41-ad97-d2b51417e6dd","slug":"renal-potassium-secretion","display_name":"Distal renal potassium secretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"abaf0468-2e37-5117-a5fc-21668c617b0a","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-romk-enac-conditional-k-secretory-chain-event","event_type":"biochemical_relationship","label":"Sodium entry changes the electrical conditions for potassium exit; 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unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"magnesium -> sodium -> potassium","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Dietary restriction in C57BL/6J mice with renal transport assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Integrated mechanism supported across experiments; enhanced distal Na delivery was not demonstrated and is not required by these data.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Sodium entry changes the electrical conditions for potassium exit; lifting the Mg brake on ROMK matters when that driving force is available.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[maeoka-2025-enac-romk] Hypomagnesaemia-associated hypokalaemia requires activation of both ENaC and ROMK (2025). https://pubmed.ncbi.nlm.nih.gov/41137719/ DOI: 10.1113/JP287704\n[yang-2010-romk-magnesium] Magnesium modulates ROMK channel-mediated potassium secretion (2010). https://pubmed.ncbi.nlm.nih.gov/21030597/ DOI: 10.1681/ASN.2010060617","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"spatial_transport_direction","value_text":"Na+: tubular lumen to cell via ENaC; K+: cell to lumen via ROMK.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Kidney distal nephron","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"a8ce5f40-dab2-5b6a-8607-8d39c93a7238","evidence_kind":"source_excerpt","locator":"Lines 203-215","start_line":203,"end_line":215,"excerpt":"### mg-romk-enac-conditional-k-secretory-chain\nThe mouse findings support a model in which sustained ENaC sodium entry and higher ROMK conductance jointly favor potassium secretion during combined Na/Mg restriction.\nCondition category: nutrient_deficiency\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Sodium entry changes the electrical conditions for potassium exit; lifting the Mg brake on ROMK matters when that driving force is available.\norganism: Mus musculus\ntissue_or_cell_type: Kidney distal nephron\nexperimental_model: Dietary restriction in C57BL/6J mice with renal transport assays\nlimitations: Integrated mechanism supported across experiments; enhanced distal Na delivery was not demonstrated and is not required by these data.\ncross_nutrient: magnesium -> sodium -> potassium\nspatial_transport_direction: Na+: tubular lumen to cell via ENaC; K+: cell to lumen via ROMK.\n[maeoka-2025-enac-romk] Hypomagnesaemia-associated hypokalaemia requires activation of both ENaC and ROMK (2025). https://pubmed.ncbi.nlm.nih.gov/41137719/ DOI: 10.1113/JP287704\n[yang-2010-romk-magnesium] Magnesium modulates ROMK channel-mediated potassium secretion (2010). https://pubmed.ncbi.nlm.nih.gov/21030597/ DOI: 10.1681/ASN.2010060617","model_system":"Dietary restriction in C57BL/6J mice with renal transport assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [maeoka-2025-enac-romk] Hypomagnesaemia-associated hypokalaemia requires activation of both ENaC and ROMK (2025). https://pubmed.ncbi.nlm.nih.gov/41137719/ DOI: 10.1113/JP287704; [yang-2010-romk-magnesium] Magnesium modulates ROMK channel-mediated potassium secretion (2010). https://pubmed.ncbi.nlm.nih.gov/21030597/ DOI: 10.1681/ASN.2010060617","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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