{"id":"914227ac-d33e-5375-aade-f4956d9ee9e7","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-lymphocyte-proliferation","predicate":"reduces","statement":"Five micromolar astaxanthin reduced proliferation of activated human lymphocytes while changing ROS, nitric oxide and calcium responses.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"336ecf47-0c89-55d9-afce-03221a2bfe04","mechanism_event_label":"Less oxidative activity did not mean every immune function increased.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"9ef50675-7228-5ea1-acf3-727997f7764b","slug":"human-astaxanthin-lymphocyte-proliferation","display_name":"Activated human lymphocyte proliferation after astaxanthin","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"336ecf47-0c89-55d9-afce-03221a2bfe04","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-lymphocyte-proliferation-event","event_type":"observed_relationship","label":"Less oxidative activity did not mean every immune function increased.","description":"Five micromolar astaxanthin reduced proliferation of activated human lymphocytes while changing ROS, nitric oxide and calcium responses.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9ef50675-7228-5ea1-acf3-727997f7764b","slug":"human-astaxanthin-lymphocyte-proliferation","display_name":"Activated human lymphocyte proliferation after astaxanthin","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ex-vivo activated human lymphocytes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Suppressed proliferation in culture is not proof of impaired human infection resistance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Less oxidative activity did not mean every immune function increased.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Astaxanthin prevents in vitro auto-oxidative injury in human lymphocytes. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20229275/ · DOI 10.1007/s10565-010-9156-4","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fb88a00f-691e-552e-8a75-7f13dd4dc79b","evidence_kind":"source_excerpt","locator":"Lines 374-380","start_line":374,"end_line":380,"excerpt":"## astaxanthin-lymphocyte-proliferation\nLess oxidative activity did not mean every immune function increased.\nFive micromolar astaxanthin reduced proliferation of activated human lymphocytes while changing ROS, nitric oxide and calcium responses.\nModel: Ex-vivo activated human lymphocytes.\nLimitations: Suppressed proliferation in culture is not proof of impaired human infection resistance.\nEvidence access: Primary abstract\nAstaxanthin prevents in vitro auto-oxidative injury in human lymphocytes. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20229275/ · DOI 10.1007/s10565-010-9156-4","model_system":"Ex-vivo activated human lymphocytes.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"98640e32f62e6c0387578165342ad21b3d2325701fcfdbb5c48886c783040e5e","revision_id":"a82757ce-1feb-582c-a5fc-f7de36308f1f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}