{"id":"9137b235-7080-56d7-860b-a193c98a22ac","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-training-fiber-growth","predicate":"with_training_increased","statement":"Muscle-fiber cross-sectional area and fat-free mass increased more with creatine than placebo during the 12-week resistance program.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"35f180c3-7281-52af-bdeb-88aee2bfd1da","mechanism_event_label":"The study found tissue and body-composition changes as well as strength changes.","subject":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"object":{"id":"f8868e74-0596-516b-b9f8-e9bce977e5bc","slug":"muscle-fiber-area","display_name":"Skeletal-muscle fiber cross-sectional area","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"35f180c3-7281-52af-bdeb-88aee2bfd1da","stable_key":"44737fa3-b335-53f4-a644-b9878d4416ac:creatine-training-fiber-growth-event","event_type":"observed_intervention","label":"The study found tissue and body-composition changes as well as strength changes.","description":"Muscle-fiber cross-sectional area and fat-free mass increased more with creatine than placebo during the 12-week resistance program.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9f5df558-ed3d-5cda-b5ca-0f90f7aa6a8c","slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f8868e74-0596-516b-b9f8-e9bce977e5bc","slug":"muscle-fiber-area","display_name":"Skeletal-muscle fiber cross-sectional area","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/creatine-research/10449017.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"945065c1e6c32f344bfc4092d1306d6ebed2354e688efe65bd73702af096729e\", \"start_char\": 0, \"end_char\": 1770, \"text_sha256\": \"945065c1e6c32f344bfc4092d1306d6ebed2354e688efe65bd73702af096729e\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Twelve-week randomized resistance-training trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"25 g/day creatine for one week then 5 g/day, with standardized resistance training","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small male training study; mechanistic explanations for greater training adaptation are hypotheses, not directly established signaling pathways.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Creatine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"creatine","display_name":"Creatine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"19 resistance-trained men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The study found tissue and body-composition changes as well as strength changes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[creatine-p10449017] Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. 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