{"id":"910628b1-8361-5b3c-8e56-29545169630f","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-benzoyl-glucuronide","predicate":"yields_metabolite","statement":"Benzoyl glucuronide was identified among urinary cinnamaldehyde-derived metabolites in the rodent study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d25d3e85-f112-55bc-8a08-bcdffcc9249c","mechanism_event_label":"A glucuronide conjugate was another exit route.","subject":{"id":"2dc093c6-9373-5b24-a17b-a6b21b5a0432","slug":"trans-cinnamaldehyde","display_name":"trans-Cinnamaldehyde / cinnamal","entity_type_key":"small_molecule"},"object":{"id":"3387a776-4469-57e3-96ae-6301cd90fdd8","slug":"benzoyl-glucuronide","display_name":"Benzoyl glucuronide","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"d25d3e85-f112-55bc-8a08-bcdffcc9249c","stable_key":"3d41d18a-e13a-59a0-a081-55bfcdd43e55:ceylon-benzoyl-glucuronide-event","event_type":"biochemical_relationship","label":"A glucuronide conjugate was another exit route.","description":"Benzoyl glucuronide was identified among urinary cinnamaldehyde-derived metabolites in the rodent study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2dc093c6-9373-5b24-a17b-a6b21b5a0432","slug":"trans-cinnamaldehyde","display_name":"trans-Cinnamaldehyde / cinnamal","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3387a776-4469-57e3-96ae-6301cd90fdd8","slug":"benzoyl-glucuronide","display_name":"Benzoyl glucuronide","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/ceylon-research/7959441.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"5bab6bd0ad082e4064c601368d147bfcd87566a98ba749a37974fb1057e8c1be\", \"start_char\": 0, \"end_char\": 1564, \"text_sha256\": \"5bab6bd0ad082e4064c601368d147bfcd87566a98ba749a37974fb1057e8c1be\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Radiolabeled disposition experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"2 or 250 mg/kg intraperitoneal, with an additional 250 mg/kg oral arm","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"High experimental exposures and rodent species; metabolite recovery does not quantify human nutrient demand or identify every enzyme.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ceylon","display_name":"Ceylon cinnamon / Cinnamomum verum bark preparations","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Rats and mice","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A glucuronide conjugate was another exit route.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ceylon-p7959441] Studies on trans-cinnamaldehyde. 1. 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