{"id":"90bc4d4d-f471-5446-acb8-ced0ddccda43","stable_key":"e37461ea-ea5d-5e2c-8091-138305f6dd70:l-aspartate-purine-rescue","predicate":"restores_selected_purine_pools","statement":"Aspartate supplementation relieved IMP accumulation and restored AMP and SAICAR pools in respiration-impaired 143B cells, while GMP did not similarly recover.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"53536f88-1ae2-5db2-a870-d5cf51780bfd","mechanism_event_label":"Restoring one substrate repaired some nucleotide steps without repairing all of them.","subject":{"id":"0a0923d3-72b7-5d6a-bf3a-5a7a3071a09b","slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"},"object":{"id":"e04546e1-9436-5fed-af5f-3c9fa5c4f05e","slug":"human-143b-adenine-nucleotide-pools","display_name":"Adenine nucleotide pools in respiration-impaired human 143B cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"53536f88-1ae2-5db2-a870-d5cf51780bfd","stable_key":"e37461ea-ea5d-5e2c-8091-138305f6dd70:l-aspartate-purine-rescue-event","event_type":"observed_relationship","label":"Restoring one substrate repaired some nucleotide steps without repairing all of them.","description":"Aspartate supplementation relieved IMP accumulation and restored AMP and SAICAR pools in respiration-impaired 143B cells, while GMP did not similarly recover.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0a0923d3-72b7-5d6a-bf3a-5a7a3071a09b","slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e04546e1-9436-5fed-af5f-3c9fa5c4f05e","slug":"human-143b-adenine-nucleotide-pools","display_name":"Adenine nucleotide pools in respiration-impaired human 143B cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d47321ac-44bb-5a88-afdb-6435b57a91b9","slug":"amp","display_name":"AMP","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"283ed24b-06a1-50aa-9281-df3bac6ce37e","slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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