{"id":"90ad22fa-0ede-51a5-8e5f-f029abc6fdcc","stable_key":"05a3cf47-e660-5ab3-8c32-5eba9847cf0a:thc-psychosis-predisposition-interaction","predicate":"modulates","statement":"After adjustment for age, sex, socioeconomic status, urbanicity, childhood trauma, baseline predisposition and other drug, tobacco and alcohol use, cannabis use raised the cumulative incidence of psychotic symptoms four years later with an adjusted odds ratio of 1.67, and the effect was much stronger in those with any predisposition at baseline, a 23.8 percentage point risk difference against 5.6 in those without.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"96fed685-d017-5d39-8350-b9d803da3a76","mechanism_event_label":"The risk lands overwhelmingly on people already predisposed.","subject":{"id":"d52b45ac-ee14-5d60-b154-fdf119f2affa","slug":"psychosis-predisposition","display_name":"Pre-existing predisposition for psychosis","entity_type_key":"cellular_process"},"object":{"id":"f762394a-7d77-5bcf-a1dc-5aaae8e3c34e","slug":"psychotic-symptoms","display_name":"Psychotic symptoms","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"96fed685-d017-5d39-8350-b9d803da3a76","stable_key":"05a3cf47-e660-5ab3-8c32-5eba9847cf0a:thc-psychosis-predisposition-interaction-event","event_type":"observed_intervention","label":"The risk lands overwhelmingly on people already predisposed.","description":"After adjustment for age, sex, socioeconomic status, urbanicity, childhood trauma, baseline predisposition and other drug, tobacco and alcohol use, cannabis use raised the cumulative incidence of psychotic symptoms four years later with an adjusted odds ratio of 1.67, and the effect was much stronger in those with any predisposition at baseline, a 23.8 percentage point risk difference against 5.6 in those without.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"efdbf605-8ade-57af-aa1b-7e907af2ffa5","slug":"cannabis-use","display_name":"Cannabis use","entity_type_key":"cellular_process"},"role":"exposure","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d52b45ac-ee14-5d60-b154-fdf119f2affa","slug":"psychosis-predisposition","display_name":"Pre-existing predisposition for psychosis","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f762394a-7d77-5bcf-a1dc-5aaae8e3c34e","slug":"psychotic-symptoms","display_name":"Psychotic symptoms","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/thc-research/15574485.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"56846f52ea834853e8aa27f64700905e072d53611066a7c58df74269b65ec290\", \"start_char\": 0, \"end_char\": 1860, \"text_sha256\": \"56846f52ea834853e8aa27f64700905e072d53611066a7c58df74269b65ec290\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Prospective cohort of 2437 young people with baseline predisposition assessment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Cannabis use at baseline with psychotic symptoms at four-year follow-up","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A prospective design with adjustment for predisposition, trauma and other drugs, which is what makes the interaction finding interpretable.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates.","comparator":null,"unit":null,"notes":"","entity":{"slug":"tetrahydrocannabinol","display_name":"Delta-9-tetrahydrocannabinol / THC","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The risk lands overwhelmingly on people already predisposed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[thc-p15574485] Prospective cohort study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people. (2005). https://pubmed.ncbi.nlm.nih.gov/15574485/ DOI: 10.1136/bmj.38267.664086.63","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole body","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b03eed50-0bb9-5500-b584-cf84e3541d4b","evidence_kind":"source_excerpt","locator":"Lines 595-606","start_line":595,"end_line":606,"excerpt":"### thc-psychosis-predisposition-interaction\nAfter adjustment for age, sex, socioeconomic status, urbanicity, childhood trauma, baseline predisposition and other drug, tobacco and alcohol use, cannabis use raised the cumulative incidence of psychotic symptoms four years later with an adjusted odds ratio of 1.67, and the effect was much stronger in those with any predisposition at baseline, a 23.8 percentage point risk difference against 5.6 in those without.\nCondition category: normal\nnutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates.\nplain_language: The risk lands overwhelmingly on people already predisposed.\norganism: Human\ntissue_or_cell_type: Whole body\nexperimental_model: Prospective cohort of 2437 young people with baseline predisposition assessment\nlimitations: A prospective design with adjustment for predisposition, trauma and other drugs, which is what makes the interaction finding interpretable.\nexposure: Cannabis use at baseline with psychotic symptoms at four-year follow-up\nevidence_span: {\"source_cache\": \"artifacts/thc-research/15574485.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"56846f52ea834853e8aa27f64700905e072d53611066a7c58df74269b65ec290\", \"start_char\": 0, \"end_char\": 1860, \"text_sha256\": \"56846f52ea834853e8aa27f64700905e072d53611066a7c58df74269b65ec290\"}\n[thc-p15574485] Prospective cohort study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people. 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