{"id":"90a7bb93-d881-5c09-a465-a5b837ae8f06","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:aasa-p6c-equilibrium","predicate":"equilibrates_with","statement":"Alpha-aminoadipate semialdehyde interconverts with its cyclic Schiff base P6C.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"fd7933d0-51de-5a3b-bdd3-a394bf9dcf78","mechanism_event_label":"One intermediate exists in open-chain and ring forms.","subject":{"id":"7d67a576-2d6f-5556-863c-d1dfd273f687","slug":"alpha-aminoadipate-semialdehyde","display_name":"alpha-Aminoadipate semialdehyde","entity_type_key":"small_molecule"},"object":{"id":"9a7b1d83-ebb2-5dea-b4a7-c040502fba4d","slug":"piperideine-6-carboxylate","display_name":"Delta1-piperideine-6-carboxylate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"fd7933d0-51de-5a3b-bdd3-a394bf9dcf78","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:aasa-p6c-equilibrium-event","event_type":"biochemical_relationship","label":"One intermediate exists in open-chain and ring forms.","description":"Alpha-aminoadipate semialdehyde interconverts with its cyclic Schiff base P6C.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7d67a576-2d6f-5556-863c-d1dfd273f687","slug":"alpha-aminoadipate-semialdehyde","display_name":"alpha-Aminoadipate semialdehyde","entity_type_key":"small_molecule"},"role":"reactant","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9a7b1d83-ebb2-5dea-b4a7-c040502fba4d","slug":"piperideine-6-carboxylate","display_name":"Delta1-piperideine-6-carboxylate","entity_type_key":"small_molecule"},"role":"product","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Biochemical characterization","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The two chemical species are separate entities connected by equilibrium.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"One intermediate exists in open-chain and ring forms.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mills2006] Mutations in antiquitin in individuals with pyridoxine-dependent seizures. (2006). https://pubmed.ncbi.nlm.nih.gov/16491085/ DOI: 10.1038/nm1366","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Lysine-catabolizing compartments and body fluids","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5e8ea65b-dd98-5822-8781-9dcb2a2019cb","evidence_kind":"source_excerpt","locator":"Lines 94-102","start_line":94,"end_line":102,"excerpt":"### aasa-p6c-equilibrium\nAlpha-aminoadipate semialdehyde interconverts with its cyclic Schiff base P6C.\nPlain language: One intermediate exists in open-chain and ring forms.\nCondition category: normal\norganism: Homo sapiens\ntissue_or_cell_type: Lysine-catabolizing compartments and body fluids\nexperimental_model: Biochemical characterization\nlimitations: The two chemical species are separate entities connected by equilibrium.\n[mills2006] Mutations in antiquitin in individuals with pyridoxine-dependent seizures. (2006). https://pubmed.ncbi.nlm.nih.gov/16491085/ DOI: 10.1038/nm1366","model_system":"Biochemical characterization","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact quote from the accompanying curation document, not from publisher text. Original study references: [mills2006] Mutations in antiquitin in individuals with pyridoxine-dependent seizures. (2006). https://pubmed.ncbi.nlm.nih.gov/16491085/ DOI: 10.1038/nm1366","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7633bde7-dcc9-5086-91c6-a45eb96857f3","stable_key":"import-c3df3634-4c3a-5099-a5d9-e4f6344c1084","title":"L-Lysine: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"93998d47c21525409ba82f1c82ededf2893dff15fbe61c7deffc175b0e298e97","revision_id":"3897e31f-6624-59e1-a053-8a81b7361632","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}