{"id":"907846f7-9bda-580b-9967-5c0d7afb4304","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-vascular-dose","predicate":"reduces","statement":"Thirty grams intravenously reduced peripheral resistance by 10.4% and blood pressure by 4.4%; 6 g orally or intravenously did not significantly change them.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"63e9a633-a56e-5370-856d-7569e33c2c14","mechanism_event_label":"A vascular effect depended on the tested exposure.","subject":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"object":{"id":"77c2fd4c-d053-5963-b17b-12750eb06f33","slug":"systemic-vascular-resistance","display_name":"Systemic vascular resistance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"63e9a633-a56e-5370-856d-7569e33c2c14","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-vascular-dose-event","event_type":"observed_relationship","label":"A vascular effect depended on the tested exposure.","description":"Thirty grams intravenously reduced peripheral resistance by 10.4% and blood pressure by 4.4%; 6 g orally or intravenously did not significantly change them.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"77c2fd4c-d053-5963-b17b-12750eb06f33","slug":"systemic-vascular-resistance","display_name":"Systemic vascular resistance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Eight healthy men; acute route/dose comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not evidence of a long-term cardiovascular benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Arginine collection; tissue, species, dose and formulation distinctions retained.","comparator":null,"unit":null,"notes":"","entity":{"slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A vascular effect depended on the tested exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9833603/ · DOI 10.1046/j.1365-2125.1998.00803.x","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"30f2fb9c-82ed-5c2b-8a48-d6a48d1d57e2","evidence_kind":"source_excerpt","locator":"Lines 366-372","start_line":366,"end_line":372,"excerpt":"## arg-vascular-dose\nA vascular effect depended on the tested exposure.\nThirty grams intravenously reduced peripheral resistance by 10.4% and blood pressure by 4.4%; 6 g orally or intravenously did not significantly change them.\nModel: Eight healthy men; acute route/dose comparison.\nLimitations: Not evidence of a long-term cardiovascular benefit.\nEvidence access: Primary abstract\nL-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9833603/ · DOI 10.1046/j.1365-2125.1998.00803.x","model_system":"Eight healthy men; acute route/dose comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; primary evidence access stated per claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bb9a67ea-904f-5b8a-93a4-459081212bdd","stable_key":"import-fd37d270-3395-56d6-9f1c-ddda56e606f6","title":"L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"ec0e9a3fb72b7485534e4372a074ac7624a399ff962e55690eb462217b5149ec","revision_id":"af027270-5535-51ae-85ff-9c76c518c962","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}