{"id":"90149db7-2d07-5234-a8be-9cc689aebfc8","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iodine-trans-intestinal-sodium-uptake","predicate":"supports","statement":"Rodent intestinal brush-border membrane vesicles accumulated iodide in a sodium-dependent, perchlorate-sensitive manner.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"3ae90bdd-4331-577e-adf0-6e597c30f7dc","mechanism_event_label":"Intestinal iodide uptake can use the sodium gradient.","subject":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"object":{"id":"759b6f24-098d-5b19-b891-a5ad49fade50","slug":"cellular-iodide-uptake","display_name":"Cellular iodide uptake","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3ae90bdd-4331-577e-adf0-6e597c30f7dc","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iodine-trans-intestinal-sodium-uptake-event","event_type":"biochemical_relationship","label":"Intestinal iodide uptake can use the sodium gradient.","description":"Rodent intestinal brush-border membrane vesicles accumulated iodide in a sodium-dependent, perchlorate-sensitive manner.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"cotransported_ion","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"role":"transported_substrate","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ada0a331-72b2-557f-84f6-8583fab1129c","slug":"perchlorate-ion","display_name":"Perchlorate ion","entity_type_key":"ion"},"role":"inhibitor","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"759b6f24-098d-5b19-b891-a5ad49fade50","slug":"cellular-iodide-uptake","display_name":"Cellular iodide uptake","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"true","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat and mouse intestinal localization, intestinal brush-border vesicles and IEC-6 cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Sodium-dependent vesicle uptake with perchlorate inhibition; concentrations not verified from abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The abstract does not assign every vesicle experiment to one rodent species; the claim preserves the rodent scope and does not attribute the protein to humans.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rodent intestinal preparation; rat and mouse study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Intestinal iodide uptake can use the sodium gradient.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iodine-trans-intestine2009] The Na+/I- symporter mediates active iodide uptake in the intestine. (2009). https://pubmed.ncbi.nlm.nih.gov/19052257/ DOI: 10.1152/ajpcell.00509.2008","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestinal brush-border membrane vesicles","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d143bf12-6b20-52a9-8737-d47e07a798bf","evidence_kind":"source_excerpt","locator":"Lines 258-269","start_line":258,"end_line":269,"excerpt":"### iodine-trans-intestinal-sodium-uptake\nRodent intestinal brush-border membrane vesicles accumulated iodide in a sodium-dependent, perchlorate-sensitive manner.\nCondition category: normal\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Intestinal iodide uptake can use the sodium gradient.\norganism: Rodent intestinal preparation; rat and mouse study\ntissue_or_cell_type: Intestinal brush-border membrane vesicles\nexperimental_model: Rat and mouse intestinal localization, intestinal brush-border vesicles and IEC-6 cells\nlimitations: The abstract does not assign every vesicle experiment to one rodent species; the claim preserves the rodent scope and does not attribute the protein to humans.\nexposure: Sodium-dependent vesicle uptake with perchlorate inhibition; concentrations not verified from abstract.\ncross_nutrient: true\n[iodine-trans-intestine2009] The Na+/I- symporter mediates active iodide uptake in the intestine. (2009). https://pubmed.ncbi.nlm.nih.gov/19052257/ DOI: 10.1152/ajpcell.00509.2008","model_system":"Rat and mouse intestinal localization, intestinal brush-border vesicles and IEC-6 cells","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iodine-trans-intestine2009] The Na+/I- symporter mediates active iodide uptake in the intestine. (2009). https://pubmed.ncbi.nlm.nih.gov/19052257/ DOI: 10.1152/ajpcell.00509.2008","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"76da623d-a34a-5a5c-a942-d7571a85c486","stable_key":"import-aaa7baba-8689-56ab-ba1e-b71542bcb8e9","title":"Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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