{"id":"9010b1ef-2939-528b-946c-d7a0b2f3138a","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-ldl-carriage","predicate":"distributed_predominantly_into","statement":"Approximately 79% ± 9% of plasma lycopene was associated with LDL in seven participants.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b066e02a-14bc-51cd-97a2-06a5d2086d35","mechanism_event_label":"Lycopene travels with blood lipoproteins; a blood measurement also reflects its carriers.","subject":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"object":{"id":"4347a06b-57db-5166-852a-630232062f6d","slug":"lycopene-ldl-distribution","display_name":"Lycopene distribution into the LDL plasma fraction","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b066e02a-14bc-51cd-97a2-06a5d2086d35","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-ldl-carriage-event","event_type":"biochemical_relationship","label":"Lycopene travels with blood lipoproteins; a blood measurement also reflects its carriers.","description":"Approximately 79% ± 9% of plasma lycopene was associated with LDL in seven participants.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4347a06b-57db-5166-852a-630232062f6d","slug":"lycopene-ldl-distribution","display_name":"Lycopene distribution into the LDL plasma fraction","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lycopene-research/7562097.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a8e551bad4ddb5e7eb7d3c8d796a94532e7f4701e891d9daae92a44bfb04179b\", \"start_char\": 0, \"end_char\": 1620, \"text_sha256\": \"a8e551bad4ddb5e7eb7d3c8d796a94532e7f4701e891d9daae92a44bfb04179b\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Plasma lipoprotein fractionation and ex-vivo incubation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Native plasma distributions and incubation experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small descriptive study; distribution is not proof that raising LDL improves delivery or health.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lycopene research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human, seven normolipidemic participants","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Lycopene travels with blood lipoproteins; a blood measurement also reflects its carriers.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lycopene-p7562097] Distributions of carotenoids and alpha-tocopherol among lipoproteins do not change when human plasma is incubated in vitro. 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