{"id":"8fd215be-85fb-5968-afb9-cac273659859","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-glucose-response","predicate":"reduces_tested","statement":"The MSG-plus-carbohydrate condition had lower peak serum glucose than carbohydrate alone, 5.50 versus 7.69 mmol/L.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"250095ac-d1bf-5ee0-a96b-2c42745f0f3b","mechanism_event_label":"A measured glucose effect does not by itself reveal the enzyme responsible.","subject":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"object":{"id":"f29fb376-3be3-5c7f-be94-98f80253dbaf","slug":"human-staggered-msg-glucose-response","display_name":"Human glucose response after staggered MSG/carbohydrate ingestion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"250095ac-d1bf-5ee0-a96b-2c42745f0f3b","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-glucose-response-event","event_type":"observed_relationship","label":"A measured glucose effect does not by itself reveal the enzyme responsible.","description":"The MSG-plus-carbohydrate condition had lower peak serum glucose than carbohydrate alone, 5.50 versus 7.69 mmol/L.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f29fb376-3be3-5c7f-be94-98f80253dbaf","slug":"human-staggered-msg-glucose-response","display_name":"Human glucose response after staggered MSG/carbohydrate ingestion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8ae7848b-f172-5e09-8acf-5ca914907b0b","slug":"glucose","display_name":"D-glucose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same nine-person acute study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No diabetes-treatment efficacy or durable metabolic benefit was tested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Monosodium Glutamate (MSG) collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A measured glucose effect does not by itself reveal the enzyme responsible.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Glutamate supplementation is associated with improved glucose metabolism following carbohydrate ingestion in healthy males. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23750536/ · DOI 10.1017/S0007114513001633","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a7d6d7c4-894e-5184-acfc-daa4bc229d50","evidence_kind":"source_excerpt","locator":"Lines 58-64","start_line":58,"end_line":64,"excerpt":"## monosodium-glutamate-glucose-response\nA measured glucose effect does not by itself reveal the enzyme responsible.\nThe MSG-plus-carbohydrate condition had lower peak serum glucose than carbohydrate alone, 5.50 versus 7.69 mmol/L.\nModel: Same nine-person acute study.\nLimitations: No diabetes-treatment efficacy or durable metabolic benefit was tested.\nEvidence access: Primary abstract\nGlutamate supplementation is associated with improved glucose metabolism following carbohydrate ingestion in healthy males. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23750536/ · DOI 10.1017/S0007114513001633","model_system":"Same nine-person acute study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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